Ostrogski (Polish: Ostrogscy, Lithuanian: Ostrogiškiai, Ukrainian: Острозькі-Ostroz'ki, Belarusian: Астрожскія, "Астроскія", Russian: Острожские -Ostrozhskie) was one of the greatest Polish-Ruthenian families of the Grand Duchy of Lithuania, which was then part of the Polish-Lithuanian Commonwealth. The family spanned from the 14th century Daniil Ostrogski to the 17th century Janusz Ostrogski. All family's possessions were passed to the Zasławski family.
They were most likely of Rurikid stock and descended from Sviatopolk II of Kiev. Some scholars however claim their descent from Galicia-Volhynia line of Rurikid dynasty. Vasilko Romanovich (c.1256-1282) Prince of Slonim may have been grandfather of Prince Daniel Ostrogski. The probable progenitor of this family was Prince Danylo Dmytrovych (or Danylo Wasilijewicz), who received Ostroh from Liubartas, King of Galicia-Volhynia and son of Grand Duke of Lithuania Gediminas. His son, Prince Feodor Danilovich Ostrogski, was a supporter of King Jagiello, who in 1386 confirmed him in possession of the Ostroh Castle and appointed governor of Volhynia in 1387. In addition to Ostrog Feodor Danilovich Ostrogski became owner of Korets, Zaslav (Izyaslav, in present Khmelnytskyi Oblast, Ukraine), and other towns. In some chronicles Feodor is called Dux Fethko de Ostrog. Their dominions in Volynia, Galicia, and Podolia included 24 towns, 10 townlets, and more than 100 villages.