Osteostimulation

Osteostimulation is a technique attempted for improving healing of bone injuries or defects. It has not however been found to be significantly effective in increasing bone healing.

It is believed to work through the active stimulation of osteoblast proliferation and differentiation as evidenced by increased levels of DNA synthesis and of the osteoblast markers osteocalcin and alkaline phosphatase. Through an ionic exchange, Bioglass first acts as a scaffolding around and through which new bone forms. In vivo studies have demonstrated that the osteostimulative properties result in stimulation and acceleration of new bone formation in an osseous defect. (FDA 510(k) clearance, February 2006 for PerioGlas).