![]() |
This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (February 2007) |
This article may contain inappropriate or misinterpreted citations that do not verify the text. Please help improve this article by checking for inaccuracies. (help, talk, get involved!) (February 2007) |
Orthopoxvirus | |
---|---|
Virus classification | |
Group: | Group I (dsDNA) |
Order: | Unassigned |
Family: | Poxviridae |
Subfamily: | Chordopoxvirinae |
Genus: | Orthopoxvirus |
Type species | |
Vaccinia virus |
|
Species | |
Camelpox virus |
Orthopoxvirus is a genus of poxviruses that includes many species isolated from mammals, such as Camelpox virus, Cowpox virus, Ectromelia virus, Monkeypox virus, and Volepox virus, which causes mousepox. The most famous member of the genus is Variola virus, which causes smallpox. It was wiped out using another orthopoxvirus, the Vaccinia virus, as a vaccine.
Contents |
Some orthopoxviruses have the ability to infect non-host species, such as Monkeypox virus, which is capable of establishing infection in humans. Zoonoses of many of these mammalian isolates have been reported. Others, such as Ectromelia virus, are very specific for their hosts.
Aerosols of concentrated virus may result in orthopox infection, especially in non-immunized individuals. Needle sticks, especially with concentrated virus, may result in severe local infection of the skin even in immunized individuals.
The initial symptoms include fever, malaise, head and body aches, and sometimes vomiting. Lesions that developed into crater-like ulcers surrounded by inflammatory tissue and eventually covered by thick black crusts are the characteristic indicators of orthopox infection. Severe edema and erythema may affect large areas in cases of severe infection. Encephalitis (alteration of mental status and focal neurologic deficits), myelitis (upper- and lower-motor neuron dysfunction, sensory level and bowel and bladder dysfunction), or both may result from Orthopoxvirus infection. Rarely, orthopoxviruses may be detected in cerebrospinal fluid. Some mammalian orthopox infections are known to result in high instances of mortality.
Vaccinia-specific immunoglobulins may be administered to infected individuals. The only product currently available for treatment of complications of orthopox infection is vaccinia immunoglobulin (VIG), which is an isotonic sterile solution of the immunoglobulin fraction of plasma from persons vaccinated with vaccinia vaccine. It is effective for treatment of eczema vaccinatum and certain cases of progressive vaccinia. However, VIG is contraindicated for the treatment of vaccinial keratitis. VIG is recommended for severe generalized vaccinia if the patient is extremely ill or has a serious underlying disease. VIG provides no benefit in the treatment of postvaccinal encephalitis and has no role in the treatment of smallpox. Current supplies of VIG are limited, and its use should be reserved for treatment of vaccine complications with serious clinical manifestations. The recommended dosage of the currently available VIG for treatment of complications is 0.6 ml/kg of body weight. VIG must be administered intramuscularly and should be administered as early as possible after the onset of symptoms. Because therapeutic doses of VIG might be substantial (e.g., 42 ml for a person weighing 70 kg), the product should be administered in divided doses over a 24- to 36-hour period. Doses can be repeated, usually at intervals of 2–3 days, until recovery begins (e.g., no new lesions appear). Future reformulations of VIG might require intravenous administration, and health-care providers should refer to the manufacturer's package insert for correct dosages and route of administration. CDC is currently the only source of VIG for civilians (see Vaccinia Vaccine Availability for contact information). The Food and Drug Administration has not approved the use of any antiviral compound for the treatment of vaccinia virus infections or other Orthopoxvirus infections, including smallpox. Certain antiviral compounds (ST-246)[1] have been reported to be 100% active against vaccinia virus or other Orthopoxviruses in vitro and among test animals. ST-246 has been granted orphan drug status by the FDA and is currently under study to determine the safety and effectiveness in humans . Gleevec, a compound FDA approved for cancer treatment limits the release of enveloped extracellular virions and protects mice from a lethal challenge with vaccinia.[2] Currently Gleevec and related compounds are being evaluated by the CDC for their efficacy against smallpox and monkeypox. Questions also remain regarding the effective dose and the timing and length of administration of these antiviral compounds. Insufficient information exists on which to base recommendations for any antiviral compound to treat post-vaccination complications or Orthopoxvirus infections, including smallpox. However, additional information could become available, and health-care providers should consult CDC to obtain up-dated information regarding treatment options for smallpox vaccination complications (see Consultation Regarding Complications of Vaccinia Vaccine).
|
This is a list of characters appearing in the Destroy All Humans! series.
Cryptosporidium (Furon) Cryptosporidium, (also known as simply just "Crypto" for short), is the main protagonist of the entire franchise. He is part of an alien species known as Furons, he is also an anti-hero who enjoys wreaking havoc, destroying and most certainly humiliating the Earth's population and he speaks with an extremely slow and monotone voice. He is known to have a best friend/ally personality with Pox, although he does not like to admit it and enjoys pushing his buttons. He is also known to be an alcoholic, a gambler, a smoker and many other qualities of the sort. His name comes from the Cryptosporidium protist. Crypto's commanding officer is Orthopox 13, who usually gives him his missions. Sometimes, Crypto talks with a variety of wise-cracking remarks. Voiced by J. Grant Albrecht and Sean Donnellan (in Big Willy Unleashed). In the Japanese version, he is voiced by Kappei Yamaguchi.
Well the church bells are calling
Police cars on fire
And as they call you to the eye of the storm
All the people say "Stay at home tonight"
I say we are the pigs, we are the swine
We are the stars of the firing line
And as the smack cracks at your window
You wake up with a gun in your mouth
Oh let the nuclear wind blow away my sins
And I'll stay at home in my house
I say, we are the pigs
we are the swine
we are the stars of the firing line
But deceit can't save you so