Fab or FAB may refer to:
The fragment antigen-binding (Fab) fragment is a region on an antibody that binds to antigens. It is composed of one constant and one variable domain of each of the heavy and the light chain. The variable domain contains the paratope (the antigen-binding site), comprising a set of complementarity determining regions, at the amino terminal end of the monomer. Each arm of the Y thus binds an epitope on the antigen.
In an experimental setting, Fc and Fab fragments can be generated in the laboratory. The enzyme papain can be used to cleave an immunoglobulin monomer into two Fab fragments and an Fc fragment. The enzyme pepsin cleaves below hinge region, so a F(ab')2 fragment and a pFc' fragment is formed. Recently another enzyme for generation of F(ab')2 has been commercially available. The enzyme IdeS (Immunoglobulin degrading enzyme from Streptococcus pyogenes, trade name FabRICATOR) cleaves IgG in a sequence specific manner at neutral pH. The F(ab')2 fragment can be split into two Fab' fragments by mild reduction.
Fab is an e-commerce company founded in 2010. Once estimated at a worth of over 1 billion dollars, in November 2014, the company was rumored to be in talks to sell for 15 million. In March 2015, PCH International acquired Fab for an undisclosed sum.
It grew from 175,000 members in June 2011, to over 10 million as of December 2012. As of April 30, 2013, Fab has disclosed that it receives 6 million unique visitors per month and have sold over 7 million products since launch. Fab is headquartered in Manhattan and operates a warehouse in Keasbey, New Jersey. The company has office locations in NYC, Pune (India), and Berlin.
Fab was founded in February 2010 by Jason Goldberg (entrepreneur) (formerly of XING AG and Jobster) and chief designer Bradford Shellhammer. The site was originally created as a social network for gay men and their friends before pivoting on June 9, 2011 into its model of daily design inspirations and sales. In November 2011, five months after re-launching, Fab reached 1 million members. The company reached this number faster than Facebook, Twitter and Groupon. In September 2012, Fab removed the membership requirements to browse the site. In December 2012, Fab passed 10 million members, up from 7.5 million members in September. Fab also announced it had sold more than 4.3 million products since its launch, averaging 5.4 products sold per minute. In July 2013, fab eliminated 100 positions at its Berlin office as a profit-building measure. Fab laid off 101 more staff, primarily at its New York office in October 2013, further reducing their workforce by 19 percent.
Atrox is an avant-garde metal band from Trondheim, Norway. The group originally formed under the name "Suffocation" but soon changed it because of numerous other bands with the same name. Formed in 1988, the band released its first material only in 1997, and followed it with two releases on notable French metal label, Season of Mist. While their early releases are firmly rooted in death metal, later releases incorporate more progressive elements.
-viNd- - Guitars
Rune Sørgård - guitars, Programming
Tor Arne Helgesen - Drums
Erik Paulsen - Bass
Rune Folgerø - lead vocals
Per Spjøtvold - Keyboard, backing vocals
Ole Marius Larmerud - Guitars (2002–2005)
Monika Edvardsen - Vocals, Keyboard (1996–2004)
Pete Beck - Vocals, Bass (2002–2004)
Daniel Stavsøyen - Bass (2001–2002)
Tom Wahl - Bass (1999)
Dag Rune Øyan - Guitars (1995–1999)
Lars Halvard Søndrol - Drums (1994–1999)
Tommy Sebastian Halseth - Bass (1995–1999)
Geir Tore Johansen - Vocals (1988–1997)
Svenn Tore Mauseth Bass (1988–1995)
Tor-Helge Skei - Guitars (1988–1994)
Tomas Smagersjø - Drums (1993)
Geir Knarrbakk - Drums (1988–1992)
Gunder Audun Dragsten - Guitars (1988–1990)
The Orgasm is a cocktail that can be served either on the rocks or layered and drunk as a shooter.
There are many versions of this popular mixed drink. Bartending 101 gives one version as equal parts Amaretto, Kahlúa and Baileys Irish Cream. One version is "made on your B.A.C.K.", meaning it is made with Baileys, Amaretto, half and half (cream) and Kahlúa, with each ingredient having one part. Another variation contains 1/3 oz. each of Vodka, Amaretto, Triple Sec and White Crème de cacao, and 1 oz. of light cream. This variation of the recipe is sometimes known as a "Screaming Orgasm".
Since 2011, the cocktail is no longer part of the "official IBA cocktails" of the International Bartenders Association (IBA).
"Orgasm" (Japanese: オルガスム, Hepburn: Orugasumu) is the second single by Japanese heavy metal band X Japan, then named X, released on April 10, 1986.
"Orgasm" was the first release by drummer Yoshiki's own record label Extasy Records. Unusually, the band's name, X, is written on the cover in Japanese as エックス. All 1,500 copies sold out, and in his biography Yoshiki says an additional pressing of 2,500 copies was scheduled, but was cancelled as guitarist Jun and bassist Hikaru had left the band.
The song is notoriously known for the obvious sexual themes presented within the lyrics. Of particular notice is the fact that the track begins with heavy panting and ends with explosions, seemingly to emulate sexual climax. The title track as well as the self-titled "X" would later be re-recorded for the band's second album Blue Blood.
"X" has become a signature song of X Japan, being performed at nearly all of their concerts. Numerous times during a pause in a performance of the track a band member, usually vocalist Toshi, will yell "We are..." and the audience responds with "X!" before the musicians start the last leg of the song. This was used as the title to the 2016 documentary film about the group, We Are X.