Proposed top-level domain
The Domain Name System of the Internet consists of a set of top-level domains which constitute the root domain of the hierarchical name space and database. In the growth of the Internet, it became desirable to expand the set of initially six generic top-level domains in 1984. As a result new top-level domain names have been proposed for implementation by ICANN. Such proposals included a variety of models ranging from adoption of policies for unrestricted gTLDs that could be registered by anyone for any purpose, to chartered gTLDs for specialized uses by specialized organizations. In October 2000, ICANN published a list of proposals for top-level domain strings it had received.
Geographic proposals
MED28
Mediator of RNA polymerase II transcription subunit 28 is an enzyme that in humans is encoded by the MED28 gene. It forms part of the Mediator complex.
Function
Subunit Med28 of the Mediator may function as a scaffolding protein within Mediator by maintaining the stability of a submodule within the head module, and components of this submodule act together in a gene-regulatory programme to suppress smooth muscle cell differentiation. Thus, mammalian Mediator subunit Med28 functions as a repressor of smooth muscle-cell differentiation, which could have implications for disorders associated with abnormalities in smooth muscle cell growth and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle tumours.
Interactions
MED28 has been shown to interact with Merlin,Grb2 and MED26.
See also
References
This article incorporates text from the public domain Pfam and InterPro IPR021640
Further reading
MED6
Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the MED6 gene.
Protein family
This family of proteins represent the transcriptional mediator protein subunit 6 that is required for activation of many RNA polymerase II promoters and which are conserved from yeast to humans.
Interactions
MED6 has been shown to interact with:
References
Further reading
External links
This article incorporates text from the public domain Pfam and InterPro IPR007018
PTA
PTA may refer to:
