Hint

Hint and similar may refer to:

Uppercase

HINT2

Histidine triad nucleotide binding protein 2 (HINT2) is a mitochondrial protein that in humans is encoded by the HINT2 gene on chromosome 9. This protein is an AMP-lysine hydrolase and phosphoamidase and may contribute to tumor suppression.

Structure

As a member of the histidine triad nucleotide-binding (Hint) protein family, which is a subfamily of the histidine triad (HIT) family, HINT2 contains a conserved histidine and HIT sequence motif (His-X-His-X-His-X-X), and the latter two histidines contribute to a catalytic triad. The 163-amino acid protein encoded by this gene forms a 17-kDa homodimer. Compared to other members of the Hint family, HINT2 has a 61% sequence homology to HINT1 and 28% sequence homology to HINT3. When compared with HINT1, the 35–amino acid extension at the HINT2 N-terminal corresponds to a predicted mitochondria import signal.

Function

HINT1

Histidine triad nucleotide-binding protein 1 is a protein that in humans is encoded by the HINT1 gene. It is a haploinsufficient tumor suppressor gene that inhibits the Wnt/β-catenin pathway in colon cancer cells and Microphthalmia-associated transcription factor (MITF) activity in human mast cells. In the LysRS-Ap4A-MITF signaling pathway, HINT1 inhibits the MITF transcriptional activity by direct association. Upon pathway activation, HINT1 is released from MITF by diadenosine tetraphosphate (Ap4A), produced by LysRS.

References

Further reading

Woman

A woman is a female human. The term woman is usually reserved for an adult, with the term girl being the usual term for a female child or adolescent. The term woman is also sometimes used to identify a female human, regardless of age, as in phrases such as "women's rights". "Woman" may also refer to a person's gender identity. Women with typical genetic development are usually capable of giving birth from puberty until menopause. In the context of gender identity, transgender people who are biologically determined to be male and identify as women cannot give birth. Some intersex people who identify as women cannot give birth due to either sterility or inheriting one or more Y chromosomes. In extremely rare cases, people who have Swyer syndrome can give birth with medical assistance. Throughout history women have assumed or been assigned various social roles.

Etymology

The spelling of woman in English has progressed over the past millennium from wīfmann to wīmmann to wumman, and finally, the modern spelling woman. In Old English, wīfmann meant "female human", whereas wēr meant "male human". Mann or monn had a gender-neutral meaning of "human", corresponding to Modern English "person" or "someone"; however, subsequent to the Norman Conquest, man began to be used more in reference to "male human", and by the late 13th century had begun to eclipse usage of the older term wēr. The medial labial consonants f and m in wīfmann coalesced into the modern form "woman", while the initial element, which meant "female", underwent semantic narrowing to the sense of a married woman ("wife"). It is a popular misconception that the term "woman" is etymologically connected with "womb", which is from a separate Old English word, wambe meaning "stomach" (of male or female; modern German retains the colloquial term "Wampe" from Middle High German for "potbelly"). Nevertheless, such a false derivation of "woman" has appeared in print.

Woman (1918 film)

Woman is a 1918 American silent film directed by Maurice Tourneur, an allegorical film showcasing the story of women through points in time. Popular in its day, the film was distributed in the State's Rights plan as opposed to a major distributor like Paramount or Universal. This film has been preserved in private collections and in major venues like the Museum of Modern Art and reportedly the Gosfilmofond Archive in Russia.

Some scenes were shot at Bar Harbor, Maine. It was here that one of Tourneur's cameramen, John van den Broek, lost his life while filming a scene close to the raging Atlantic Ocean. His body was swept out to sea and never found.

Prints of this film are held at Cineteca Del Friuli, Germona, the Museum of Modern Art, New York, and Gosfilmofond of Russia, Moscow.

Plot

As described in a film magazine, a modern man and woman quarrel and, in reaction to his wife, the husband recalls all the women in history who have failed their husbands or lovers. Being in an unpleasant state, he recalls Adam in the garden with a very vain Eve who disports herself in a Broadway fashion and causes the downfall of caveman-like Adam. Then he dwells on the hideous betrayal of Claudius by an unfaithful Messilna. Next he recalls the useless ruination of Abelard by the charming Heloise. Following this episode he remembers Cyrene and the fisherman, where the wife basely deserted her husband and children to swim once more in her seal skin that had been hidden from her for many years. A particularly disagreeable episode in which a young woman during the American Civil War sacrifices a wounded soldier for a bauble. After this the modern woman returns and pins up a Red Cross poster, and the modern man sees the many women of today as more or less uninspiring. An epilogue noted how World War I made men realize the true value of women, and that women are working towards victory through good works in the Red Cross and other jobs.

Woman (1968 film)

Woman (여 - Yeo) is a 1968 three-part South Korean film directed by Kim Ki-young, Jung Jin-woo and Yu Hyun-mok. The film was based on ideas of Kim Ki-young's wife, Kim Yu-bong, and Kim directed the last third.

Synopsis

The film is a melodrama about a man who falls in love with a woman while traveling to Seoraksan. The man becomes infatuated with the woman's hair. The woman, who has a terminal illness, promises to leave her hair to the man after she has died. Later the man finds that the woman has died, and her hair has been sold to someone else. He then has a romantic relationship with another woman who turns out to be his mother.

Cast

Notes

Bibliography

Army

An army (from Latin arma "arms, weapons" via Old French armée, "armed" (feminine)) or ground force is a fighting force that fights primarily on land. In the broadest sense, it is the land-based military branch, service branch or armed service of a nation or state. It may also include other branches of the military such as the air force via means of aviation corps. Within a national military force, the word army may also mean a field army. They differ from army reserves who are activated only during such times as war or natural disasters.

In several countries, the army is officially called the Land Army to differentiate it from an air force called the Air Army, notably France. In such countries, the word "army" on its own retains its connotation of a land force in common usage. The current largest army in the world, by number of active troops, is the People's Liberation Army of China with 2,250,000 active troops and 800,000 reserve personnel followed by the Indian Army with 1,129,000 active troops and 2,142,900 reserve personnel.