On-and-On

On-and-On (April 24, 1956 – 1970) was an American Thoroughbred racehorse who was a top runner for owner/breeder Calumet Farm and the sire of their 1968 Kentucky Derby and Preakness Stakes winner, Forward Pass and the damsire of U.S. Racing Hall of Fame inductee Alydar.

Bred in Kentucky, On-and-On was trained by future U.S. Racing Hall of Fame inductee Jimmy Jones The colt did not develop enough to compete in any of the 1959 U.S. Triple Crown races but went on to win the Ohio Derby and at age four earned wins in important events such as the Brooklyn McLennan and Tropical Park Handicaps, setting a new track record for a mile and eighth on dirt in the latter that was only 1/5 of a second off the world record.

References

On and On (Stephen Bishop song)

"On and On" is a song by American singer/songwriter Stephen Bishop. The song became a major hit, peaking at number 11 on the U.S. Billboard Hot 100. It was his greatest hit, and spent 28 weeks on the chart. In Canada, the song peaked at number 6.

On the U.S. Easy Listening chart, "On and On" peaked at number two. It reached number three on the corresponding Canadian chart.

Despite failing to crack the Top Ten, it was the 30th ranked single by the Billboard magazine year-end chart for 1977 as a result of its almost seven-month chart run. The song appears on his 1976 album, Careless.

The song was featured in the films Anger Management, How to Deal, The Hitcher, Margot at the Wedding, and Remarkable Power.

Cover versions

Kenny Rankin covered "On and On" in 1977. His version charted concurrently with Stephen Bishop's original, reaching #110 on the U.S. Billboard Bubbling Under chart.

Track listing

Chart performance

References

External links

The Sun Is Often Out

The Sun Is Often Out (stylized as THE SUN iS OfTEN oUT) is the debut album by Longpigs, released in 1996 on U2's record label, Mother Records.

Track listing

All songs written by Crispin Hunt except where noted.

Personnel

Longpigs

Additional personnel

References

External links

C&A

C&A is an international Dutch chain of fashion retail clothing stores, with its European head offices in Vilvoorde, Belgium, and Düsseldorf, Germany. It has retail stores in many countries in Europe, Central America and South America. Its brands include Angelo Litrico, Canda, Clockhouse, Here+There, Palomino, Rodeo (ski and snowboard clothes), Westbury, Yessica, Yessica Pure, and Your Sixth Sense.

The company was founded by brothers Clemens and August Brenninkmeijer in 1841 as a Dutch textile company, taking its company name from their initials. In 1906 Clemen's son, Bernard Joseph, started discounting in Amsterdam (Rekenen in Centen, in plaats van Procenten) and by 1910 there were ten stores in the Netherlands. They were from the German Brenninkmeyer family which traded in linen and textiles since the 17th century from its hometown of Mettingen, Germany.

For many years, C&A retail clothing stores were a major presence on high streets throughout the United Kingdom. C&A also opened stores in a number of out-of-town locations, most notably its store at the Merry Hill Shopping Centre in the West Midlands, which opened in November 1989. The company's strategy of selling budget clothes from high-rent city-centre retail stores made it vulnerable to a new breed of competitors operating in cheaper, out-of-town locations, including Matalan and the rapidly expanding clothing operations of supermarket food chains such as Tesco and Asda, and to expanding high street names such as H&M, Zara, and Topshop.

Côa River

The Côa River is a tributary of the Douro River, in central and northeastern Portugal. It is one of the few Portuguese rivers that flows south to north. It flows through the municipalities of Sabugal Municipality, Almeida Municipality, Pinhel Municipality, Figueira de Castelo Rodrigo Municipality and Vila Nova de Foz Côa Municipality, all located in the Guarda District.

Thousands of ancient carvings in stone were discovered in the Côa Valley in the 1980s and 1990s. These are of particular interest due to the high concentration of Paleolithic art, and because these carvings are found outside of caves, on rocks in plain sight: Jean Clottes, a prominent French prehistorian, had confirmed that "is the biggest open air site of paleolithic art in Europe, if not in the world".

The drawings attracted worldwide attention when plans to build a hydroelectric dam across the Côa Valley threatened to submerge them. Although hydroelectric development was already well underway, outcry from locals, the scientific community and the media led to dam construction being halted in 1995 after a change in the national government following elections. A significant proportion of the drawings in the Canada do Inferno area were already underwater by that time. The Côa Valley Archaeological Park, opened in 1996 , was declared a protected UNESCO world heritage site in 1998.

Complement component 2

Complement C2 is a protein that in humans is encoded by the C2 gene. The protein encoded by this gene is part of the classical pathway of complement system, acting as a multi-domain serine protease. Deficiency of C2 has been associated with certain autoimmune diseases.

Function

In the classical and lectin pathways of complement activation, formation of the C3-convertase and C5-convertases requires binding of C2 to an activated surface-bound C4b in the presence of Mg²⁺; the resultant C4bC2 complex is then cleaved by C1s or MASP2 into C2a and C2b. It is thought that cleavage of C2 by C1s, while bound to C4b. results into a conformational rotation of C2a whereas the released C2b fragment may retain most of its original structure. C2a is the larger, enzymatically active fragment which is incorporated into the C3 convertase in this pathway, C4b2. C2b is released into the fluid phase.

References

Further reading

External links