OMA
OMA or Oma may refer to:
Communication
Engineering
Entertainment
Medicine
OMA1
Metalloendopeptidase OMA1, mitochondrial is an enzyme that in humans is encoded by the OMA1 gene. As a Metalloprotease, this protein is a substantial component of the quality control system in the inner membrane of mitochondria. Being activated by enzyme Bax and Bak, mitochondrial protease OMA1 promotes cytochrome c release which subsequently induces apoptosis.
Structure
Gene
The gene OMA1 encodes a metalloprotease, a founding member of a conserved family of membrane-embedded metallopeptidases in mitochondria. The human gene has 9 exons and locates at chromosome band 1p32.2-p32.1
Protein
The human protein Metalloendopetidase OMA1, mitochondrial is 60 kDa in size and composed of 524 amino acids. The peptide fragment 1-13 is mitochondrial transition peptide, the mature protein has a theoretical PI of 9.35.
Function
The inner membrane of mitochondrial houses two AAA proteases and these membrane-embedded peptidases were termed m- and i-AAA proteases to indicate their different topology in the inner membrane. The m-AAA protease is facing the matrix and the i-AAA protease is facing the intermembrane space. OMA1 was shown to share an overlapping proteolytic activity with m-AAA protease. However, OMA1 doesn't completely regulate the turnover of a model substrate, Oxa1, as what the m-AAA protease does. On the contrary, Oma1 only generates N- and C-terminal proteolytic fragments. Recent study showed that the mammalian mitochondrial inner membrane fusion protein OPA1 can be degraded by OMA1 when mitochondria lose membrane potential or adenosine triphosphate. Such inducible proteolysis acts as a regulatory mechanism to proteolytically inactivate of OPA1, thus preventing the fusion of the mitochondrial network.
Heintje Simons
Hendrik Nikolaas Theodoor "Heintje" Simons, later known as Hein Simons, (born 12 August 1955, Bleijerheide, a section of Kerkrade, Netherlands), is a Dutch singer and actor.
Life and career
Heintje was born the son of a coal miner who had to retire because of silicosis, reducing the family to near poverty. The family opened a small cafe where Heintje used to sing along with the jukebox. When he was 11, he entered a local singing contest. He beat 30 competitors to win the contest. Producer Addy Kleijngeld heard about him and went to audition him at his home. After hearing only a few notes, he took him on as a client and became his manager. Upon becoming wealthy, Heintje moved his family back to his father's birthplace, Neu Moresnet, Kelmis, Liège, Belgium.
He became famous as a child singer, with hit song "Mama" (written by Cesare Andrea Bixio, Bruno Cherubini and Bruno Balz) in 1967, and as a child actor, with his appearances in numerous German films in the 1960s and 1970s (some of these were dubbed into English and also Afrikaans). He enjoyed success with English songs, notably of which is "I'm Your Little Boy". In 1971, The Los Angeles Times described him as, "the hottest property in Europe." The same article quoted the Frankfurter Allgemeine Zeitung as saying of him, "No one is bigger in German show business."
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