OSU-6162 (PNU-96391) is a compound which acts as a partial agonist at both dopamine D2 receptors and 5-HT2A receptors. It acts as a dopamine stabilizer in a similar manner to the closely related drug pridopidine, and has antipsychotic, anti-addictive and anti-Parkinsonian effects in animal studies. Both enantiomers show similar activity but with different ratios of effects, with the (S) enantiomer (–)-OSU-6162 that is more commonly used in research, having higher binding affinity to D2 but is a weaker partial agonist at 5-HT2A, while the (R) enantiomer (+)-OSU-6162 has higher efficacy at 5-HT2A but lower D2 affinity.
Off with your head
Dance 'til you're dead
Heads will roll, heads will roll
Heads will roll on the floor
Glitter on the wet streets
Silver over everything
The river's all wet
You're all cold
Dripping with alchemy
Shiver stop shivering
The glitter's all wet
You're all chrome
The men cry out, the girls cry out
The men cry out, the girls cry out
The men cry out, oh no
The men cry out, the girls cry out
The men cry out, the girls cry out
The men cry out, oh no
Oh, oh, oh, oh
Off, off with your head
Dance, dance 'til you're dead
Heads will roll, heads will roll
Heads will roll on the floor
Looking glass, take the past
Shut your eyes, you realize
Looking glass, take the past
Shut your eyes, you realize
Glitter on the wet streets
Silver over everything
The glitter's all wet
You're all chrome, you're all chrome
Oh, oh, oh
Off, off, off with your head
Dance, dance, dance 'til you're dead
Off, off, off with your head
Dance, dance, dance 'til you're dead
Off, off, off with your head
Dance, dance, dance 'til you're dead
Off, off, off with your head
Dance, dance, dance 'til you're dead
Off, off, off with your head
Dance, dance, dance 'til you're dead
Off, off, off with your head