OSTM1

Osteopetrosis-associated transmembrane protein 1 is a protein that in humans is encoded by the OSTM1 gene. It is required for osteoclast and melanocyte maturation and function.

Function

This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. This is also known as autosomal recessive Albers-Schonberg disease.

The OSTM1 gene is regulated by the Microphthalmia-associated transcription factor.

Interactions

OSTM1 has been shown to interact with RGS19.

References

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Wisdom

by A

Wisdom

by: A

There's radiation in the air
It's hotter than the time of year
We maybe need to shed a layer and calm down
How about we disappear, leave it all, get out of here
Wash your face and start again, give us a break
And take the blame and leave it
Waiting for days, waiting to break
Don't want to hurt nobody
Waiting for you always waiting for you
HEY! but I want you to know
Making me pay, breaking away
Don't want to hurt nobody
Waiting for you, always waiting for you
Fire in the air tonight, fire burns behind your eyes
Took you to the dizzy heights and then you calmed down
How about we learn to drink, freaking out and suffering
A couple more, we hit the floor and that's your lot,
I don't recall you keeping
Waiting for days, waiting to break
Don't want to hurt nobody
Waiting for you always waiting for you
HEY! but I want you to know
Making me pay, breaking away
Don't want to hurt nobody
Waiting for you, always waiting for you
Waiting for you, always waiting for you
I sit all night to watch you cry, and gut your insides
I sit all night to watch you cry, i got your insides
Waiting for days, waiting to break
Don't want to hurt nobody
Waiting for you always waiting for you
HEY! but i want you to know
Making me pay, breaking away
Don't want to hurt nobody
Waiting for you, always waiting for you