C11orf1
Chromosome 11 open reading frame one, also known as C11orf1, is a protein-coding gene. It has been found by yeast two hybrid screen to bind to SETDB1 a histone protein methyltranferase enzyme. SETDB1 has been implicated in Huntington's disease, a neurodegenerative disorder.
C11orf1 is a nuclear protein with unknown function but has been shown to show preferential expression in some disease states in microarray data.
Species distribution
C11orf1 shows conservation through mammals and orthologs can be found in sea squirts and sea anemone. The below table shows some orthologs found using BLAST.
Gene
C11orf1 is located on chromosome 11 and is neighbored by:
Protein
Structure
This protein is part of the UPF0686 superfamily. This family is characterized by the presence of a domain of unknown function (DUF)1143 shared by the family. This family DUF1143 has a domain that includes almost all,149, of the 150 amino acids in the human ortholog. C11orf1 has six spicesomal variants and one unspliced variant.
ORF eins
ORF eins (German for ORF one) is an Austrian television channel. It was the first television channel in Austria, started in 1955.
ORF eins is one of four public TV channels in Austria. ORF eins broadcasts TV series and featured films, whereas ORF 2 focuses on cultural programming and information. ORF Sport Plus is the new sports channel, but, ORF eins continues broadcasting of important sports events. Since it has to compete with a wider range of German private TV channels via cable or satellite, ORF programming focuses on a mainstream audience. Unlike the German TV stations (which are generally available free-to-air), ORF eins and ORF 2 are encrypted over satellite.
Programming
ORF eins mostly shows films and episodes. In the morning a children's program called okidoki is broadcast. Popular sports like skiing, Formula One and association football are also shown on ORF eins. ORF broadcasts its news program Zeit im Bild (The Times in Pictures) and the Magazine on ORF 2. Until April 9, 2007, Zeit im Bild was shown on ORF eins and ORF 2 simultaneously at 7:30 p.m. ORF1 then began to show a daily soap opera during the eight o'clock hour, but on July 1, 2007, it was replaced by Malcolm in the Middle (which has been replaced by Two And A Half Men) due to low ratings. Aside from this, there are news programs several minutes long at various times during the day, with the name ZiB Flash. After 8 p.m., the news program, called ZiB 20, is now broadcast; which replaced the old Newsflash.
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