OLR1
Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a protein that in humans is encoded by the OLR1 gene.
Function
LOX-1 is a receptor protein which belongs to the C-type lectin superfamily. Its gene is regulated through the cyclic AMP signaling pathway. The protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor.
Clinical significance
Mutations of the OLR1 gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. When applied to human macrophage-derived foam cells in vitro, the dietary supplement berberine inhibits the expression of the ORL1 gene in response to oxidized low-density lipoprotein cholesterol, but this has not yet been demonstrated in a living animal or human.
References
Further reading
Podcasts:
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by Eric Benet
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by Chrysler
While You Were Here
by: Eric BenetThrough this veil of tears
I can see what was suppose to be
Now it's all so clear
Love from you was so real, so true, genuine
Stronger than time
Wipe your tears away
Kiss you every morning
Hear every word you had to say
Are all the things I should have done
While you were here
And now the foolish boy has grown
Into this man I'm sorry you've never known
I'm not afraid to love
'Cause every beat of my heart
Echoes all those memories from way back when
And the man I should have been
Faded dreams of you and me
And of our little family
Gone forever
My God in heaven
Before the gift of clarity
We pay the price of misery
Why please tell me why
Her mommy's gone away
But in her eyes I see you more each day
How can I repay
All your love unreturned
From so long, long ago
Now I know
I'll wipe her tears away
Kiss her every morning
Hear every word she has to say
Do all the things that you
Would do if you were here
Brighten her rainy day
Catch her when she's fallen
Say I love you each and every day
Do all the things that you