NPO mashinostroyeniya (Cyrillic: "НПО машиностроения") is a rocket design bureau based in Reutov, Russia. During the cold war it was responsible for several major weapons systems, including the SS-19 Intercontinental ballistic missile.

NPO mashinostroyeniya was founded in 1944, under the leadership of Vladimir Chelomei who directed till his death in 1984. Originally part of the OKB-51 design bureau, it relocated to Reutov, and from 1955 to 1966 was designated OKB-52 (and also OKB-52 MAP).

India is NPO's second largest customer after Russia for sale of P-70 Ametist, BrahMos, P-800 Oniks and possibly the P-500 Bazalt

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