Ahu

Ahu or AHU may refer to:

Polynesian religion

Places

People

Other uses

Easter Island

Easter Island (Rapa Nui: Rapa Nui, Spanish: Isla de Pascua) is a Chilean island in the southeastern Pacific Ocean, at the southeasternmost point of the Polynesian Triangle. Easter Island is famous for its 887 extant monumental statues, called moai, created by the early Rapa Nui people. In 1995, UNESCO named Easter Island a World Heritage Site, with much of the island protected within Rapa Nui National Park.

Polynesian people most likely settled on Easter Island sometime between 700 to 1100 CE, and created a thriving and industrious culture as evidenced by the island's numerous enormous stone moai and other artifacts. However, human activity, the introduction of the Polynesian rat and overpopulation led to gradual deforestation and extinction of natural resources which severely weakened the Rapa Nui civilization. By the time of European arrival in 1722, the island's population had dropped to 2,000–3,000 from an estimated high of approximately 15,000 just a century earlier. European diseases and Peruvian slave raiding in the 1860s further reduced the Rapa Nui population, to a low of only 111 inhabitants in 1877.

Sacubitril

Sacubitril (INN; developmental code name AHU-377) is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure. It was approved under the FDA's priority review process for use in heart failure on July 7, 2015.

Mechanism of action

Sacubitril is a prodrug that is activated to sacubitrilat (LBQ657) by de-ethylation via esterases. Sacubitrilat inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure-lowering peptides that work mainly by reducing blood volume.

See also

References

Oʻahu ʻōʻō

The O‘ahu ‘ō‘ō (Moho apicalis) is a member of the extinct genus of the ‘ō‘ōs (Moho) within the extinct family Mohoidae. It was previously regarded as member of the Australo-Pacific honeyeaters (Meliphagidae).

Description

The males reached a length of 30.5 centimeters. The wing length was 10.5 to 11.4 centimeters, the culmen was between 3.5 and 3.8 centimetres and the tarsus was between 3.4 and 3.8 centimeters. The females were smaller. The plumage was predominantly sooty black. The tail feathers were brown and had, with the exception of the two central tail feathers, white tips. Further characteristics were the white feather tufts under the axillaries and the two narrow central tail feathers which changed into fine hair-like or fibrous tips. The flanks and the undertail coverts were colored deeply yellow. The bill and the tarsus were black. Its biology is not well-studied.

Occurrence and habitat

Its habitat was the mountain forests on O‘ahu.

Extinction

The O‘ahu ‘ō‘ō was first mentioned by Andrew Bloxam. While in the Hawaiian Islands in 1825 as the naturalist on board HMS Blonde, he saw live birds which were brought to him by locals. He preserved one specimen obtained in this way. He wrote in his diary (not published until much later): "They are now very scarce in all the islands. I did not see even one in the different excursions I made, & the natives asked a high price for the very few they brought to me." Bloxam misidentified his birds as the species now called Moho nobilis.

Oahu

Oʻahu (pronounced [oˈʔɐhu]) or Oahu /oʊˈɑːhuː/, known as "The Gathering Place", is the third largest of the Hawaiian Islands; however, it is home to about two-thirds of the population of the U.S. state of Hawaii, and is the home of Honolulu International Airport. The state capital, Honolulu, is on Oʻahu's southeast coast. Including small close-in offshore islands such as Ford Island and the islands in Kaneohe Bay and off the eastern (windward) coast, it has a total land area of 596.7 square miles (1,545.4 km²), making it the 20th largest island in the United States. Along with the rest of the Hawaiian Islands, Oahu is one of the largest and northernmost islands of Polynesia.

In the greatest dimension, this volcanic island is 44 miles (71 km) long and 30 miles (48 km) across. The length of the shoreline is 227 miles (365 km). The island is the result of two separate shield volcanoes: Waiʻanae and Koʻolau, with a broad "valley" or saddle (the central Oʻahu Plain) between them. The highest point is Kaʻala in the Waiʻanae Range, rising to 4,003 feet (1,220 m) above sea level.