Neuropilin 1

Neuropilin-1 is a protein that in humans is encoded by the NRP1 gene. In humans, the neuropilin 11 gene is located at 10p11.22. This is one of two human neuropilins.

Function

NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.[supplied by OMIM]

Interactions

Neuropilin 1 has been shown to interact with Vascular endothelial growth factor A.

Implication in cancer

Neuropilin 1 has been implicated in the vascularization and progression of cancers. In vitro and in vivo mouse studies have shown membrane bound NRP1 to be proangiogenic and promotes the vascularization of prostate tumors. NRP1 expression levels have been shown to be elevated in a number of human patient tumor samples, including brain, prostate, breast, colon, and lung cancers and is associated with metastasis. Elevated NRP1 expression is also correlated with the invasiveness of non-small cell lung cancer both in vitro and in vivo.

Neuropilin 2

Neuropilin 2 (NRP2) is a protein that in humans is encoded by the NRP2 gene.

This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

References

Further reading

Channel 3

Channel 3 or TV 3 may refer to:

Television channels

TV3 (Catalonia)

TV3 (Catalan pronunciation: [ˈte ˈβe ˈtɾɛs]) is the primary television channel of Catalan public broadcaster Televisió de Catalunya, a subsidiary of the CCMA. TV3 broadcasts programs only in Catalan, with an optional dual track in the original language for some foreign-language series and movies. TV3 is also a founding member of FORTA, the Federation of Autonomic Radio and Television Organizations of Spain. It is funded by the Generalitat political organization.

History

TV3 started its trial broadcasts on 10 September 1983 (a day before the National Day of Catalonia), but its regular broadcasts started a few months later, on 16 January 1984. TV3 was the first television channel to broadcast only in Catalan. In 1985, TV3 expanded its coverage to Andorra, Northern Catalonia, the Balearic islands and the Valencian Community, also Catalan-speaking lands. One year later, TV3 inaugurated its new headquarters in Sant Joan Despí, near Barcelona.

Since 1987, TV3 has broadcast a second audio channel on almost all foreign-language series and movies with the original program audio, first using the Zweikanalton system and currently using NICAM. Local series and movies are usually broadcast in NICAM stereo, although sometimes an audio narration track for blind and visually impaired viewers is provided instead. In other occasions, an Aranese language track is provided.

TV3 (Czech Republic)

TV3 was an analogue terrestrial, cable and digital satellite television channel broadcasting in the Czech Republic. The station used to broadcast in some regions via analogue terrestrial television to 30% of the population in the Czech Republic,cable television and also via the Czechlink platform on the Eutelsat 28A satellite. TV3 was also planning to become part of the plans for digital terrestrial to increase its reach to 75% of the Czech Republic. The station closed in December 2001 after its broadcast license was revoked.

Launch

TV3 launched on May 25, 2000 using the regional frequencies of defunct television station Galaxie. The station launched at 1900 CET with a 60-minute regional news programme followed by the film Seductive Beauty. Programming on TV3 included regional breaking news programming with reporters on motorbikes alongside other general entertainment programming and the purchase of the rights to show WWE Friday Night SmackDown in 2001. The station used the tag "television for the new millennium" for its promotion, with its target audience skewed towards a young male audience. The opening night of TV3 was hit by technical glitches during the launch night news programming.