Nih (town)

Nih was a town belonging to the ancient state of Sistan, which straddles the modern border of Afghanistan and Iran.

In his 1930 book The Lands of the Eastern Caliphate, Guy Le Strange wrote:

At some distance to the west of the Zarah lake, on the Kuhistan frontier and close to the border of the Great Desert, is the town of Nih, or Nîh, which is named by earlier Arab geographers as belonging to Sîstân. Muķaddasî mentions it as a strongly fortified town, the houses of which were built of clay, water being brought down from the hills by underground channels. Nih is also referred to by Yâķût and Mustawfî, who, however, add no details, except to state that it was founded by King Ardashîr Bâbgân, though at the present day the remains of great fortifications, and the immense ruins found here, would seem to prove that in the middle-ages it had been a place of much importance.

References

Town

A town is a human settlement larger than a village but smaller than a city. The size definition for what constitutes a "town" varies considerably in different parts of the world.

Origin and use

The word town shares an origin with the German word Stadt, the Dutch word tuin, and the Old Norse tun. The German word Zaun comes closest to the original meaning of the word: a fence of any material. An early borrowing from Celtic *dunom (cf. Old Irish dun, Welsh din "fortress, fortified place, camp," dinas "city;"

In English and Dutch, the meaning of the word took on the sense of the space which these fences enclosed. In England, a town was a small community that could not afford or was not allowed to build walls or other larger fortifications, and built a palisade or stockade instead. In the Netherlands, this space was a garden, more specifically those of the wealthy, which had a high fence or a wall around them (like the garden of palace Het Loo in Apeldoorn, which was the example for the privy garden of William and Mary at Hampton Court). In Old Norse tun means a (grassy) place between farmhouses, and is still used in a similar meaning in modern Norwegian.

Town (New Jersey)

A Town in the context of New Jersey local government refers to one of five types and one of eleven forms of municipal government. While Town is often used as a shorthand to refer to a Township, the two are not the same.

The Town Act of 1895 allowed any municipality or area with a population exceeding 5,000 to become a Town through a petition and referendum process. Under the 1895 Act, a newly incorporated town was divided into at least three wards, with two councilmen per ward serving staggered two-year terms, and one councilman at large, who also served a two-year term. The councilman at large served as chairman of the town council.

The Town Act of 1988 completely revised the Town form of government and applied to all towns incorporated under the Town Act of 1895 and to those incorporated by a special charter granted by the Legislature prior to 1875. Under the 1988 Act, the mayor is also the councilman at large, serving a term of two years, unless increased to three years by a petition and referendum process. The Council under the Town Act of 1988 consists of eight members serving staggered two-year terms with two elected from each of four wards. One councilman from each ward is up for election each year. Towns with different structures predating the 1988 Act may retain those features unless changed by a petition and referendum process.

Administrative divisions of Wisconsin

The administrative divisions of Wisconsin include counties, cities, villages and towns. In Wisconsin, all of these are units of general-purpose local government. There are also a number of special purpose districts formed to handle regional concerns, such as school districts.

Whether a municipality is a city, village or town is not strictly dependent on the community's population or area, but on the form of government selected by the residents and approved by the Wisconsin State Legislature. Cities and villages can overlap county boundaries, for example the city of Whitewater is located in Walworth and Jefferson counties.

County

The county is the primary political subdivision of Wisconsin. Every county has a county seat, often a populous or centrally located city or village, where the government offices for the county are located. Within each county are cities, villages and towns. As of 2015, Wisconsin had 72 counties.

A Board of Supervisors is the main legislative entity of the county. Supervisors are elected in nonpartisan elections for two-year terms (except in Milwaukee County where the Milwaukee County Board of Supervisors served four years). In May 2013, the Wisconsin Legislature passed a bill that will reduce the terms of office from four-years to two-years for the Milwaukee County Board of Supervisors. The type of executive official in each county varies: 11 counties have a County Executive elected in a nonpartisan election for a four-year term; 20 counties have appointed County Administrators; and 41 have appointed Administrative Coordinators. Other officials include sheriffs, district attorneys, clerks, treasurers, coroners, surveyors, registers of deeds, and clerks of circuit court; these officers are elected for four-year terms. In most counties, elected coroners have been replaced by appointed medical examiners. State law permits counties to appoint a registered land surveyor in place of electing a surveyor.

Mirfentanil

Mirfentanil is a fentanyl derivative with strong selectivity for the μ opioid receptor. At lower doses, it antagonizes the analgesic effects of alfentanil and substitutes for naloxone in morphine-treated monkeys; however, it also reverses naloxone-precipitated withdrawal in pigeons trained to discriminate morphine from naloxone.

At high doses, it exhibits analgesic activity which is not fully reversed by opioid antagonists, suggesting that the drug has both opioid and non-opioid mechanisms of action.

Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.

Synthesis

Mirfentanil was synthesized via acylation of the product of the reaction of 2-chloropyrazine and 1-(2-phenylethyl)-4-piperidinone oxime with 2-Furoyl chloride.

Etazocine

Etazocine (NIH-7856) is an opioid analgesic of the benzomorphan family which was never marketed. It acts as a partial agonist of the opioid receptors, with mixed agonist and antagonist effects. In animal studies, it was shown to induce analgesia, dependency, and respiratory depression, with overall effects similar to those of morphine, but with substantially reduced potency in comparison.

See also

References

NIH (disambiguation)

NIH may refer to:

Health

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