NESS-0327

NESS-0327 is a drug used in scientific research which acts as an extremely potent and selective antagonist of the cannabinoid receptor CB₁. It is much more potent an antagonist, and more selective for the CB₁ receptor over CB₂, than the more commonly used ligand rimonabant, with a K_i at CB₁ of 350fM (i.e. 0.00035nM) and a selectivity of over 60,000x for CB₁ over CB₂. Independently, two other groups have described only modest nanomolar CB₁ affinity for this compound (125nM and 18.4nM). Also unlike rimonabant, NESS-0327 does not appear to act as an inverse agonist at higher doses, instead being a purely neutral antagonist which blocks the CB₁ receptor but does not produce any physiological effect of its own.

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Ness

Ness may refer to:

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Ness (surname)

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EarthBound

EarthBound, known as Mother 2 in Japan, is a 1994 Japanese role-playing video game co-developed by Ape Inc. and HAL Laboratory and published by Nintendo for the Super Nintendo Entertainment System video game console. As Ness and his party of four, the player travels the world to collect melodies en route to defeating the evil alien force Giygas. It is the second game of the Mother series, and the only one to be released in the English language until its predecessor was released under the name EarthBound Beginnings in 2015 as part of Wii U's Virtual Console.EarthBound was released in Japan on August 27, 1994, and in North America on June 5, 1995.

The game had a lengthy development period which spanned five years. Its making involved a number of Japanese luminaries, including writer Shigesato Itoi, musician/songwriter Keiichi Suzuki, sound designer Hirokazu Tanaka, and future Nintendo president Satoru Iwata. Themed around an idiosyncratic portrayal of Americana and Western culture, it subverted popular role-playing game traditions by featuring a real world setting while parodying numerous staples of the genre. Itoi, who directed the game, wanted it to reach non-gamers with its intentionally goofy tone. It was heavily marketed upon release via a promotional campaign which sardonically proclaimed "this game stinks".