The Neosho's headwaters are in Morris County, Kansas, and it flows southeast through Kansas. In Ottawa County, Oklahoma, the river turns south-southwest for the remainder of its course through Oklahoma. It meets the Arkansas River near the city of Muskogee, about a mile downstream of the confluence of the Arkansas River and the Verdigris River. The area of convergence of the three rivers Arkansas, Verdigris and Neosho is called "Three Forks."