Naughty Boy

Shahid Khan (born 1 January 1985), known by his stage name Naughty Boy, is an English DJ, songwriter, record producer and musician. In 2012, Khan signed a three–year publishing deal with Sony ATV, as well as a recording contract to release one album under Virgin EMI Records. Khan launched himself as a record producer under the moniker "Naughty Boy" and runs his own production company called Naughty Boy Recordings.

Naughty Boy has produced two top-ten records for UK rappers Chipmunk and Wiley, both featuring Emeli Sandé. Naughty Boy and Sandé later formed a writing and production partnership, leading to Sandé landing her own record deal with Virgin and EMI. Sandé went on to be named the Critics Choice for the 2012 BRIT Awards, and release her debut album Our Version of Events (2012), a record co-written/produced with Naughty Boy. Khan spent 2011 and 2012 working on records for Leona Lewis, JLS, Cheryl Cole, Jennifer Hudson, Alesha Dixon and Tinie Tempah, among others.

In 2013, Naughty Boy released his debut album Hotel Cabana. The set features prominent collaborator Sandé, as well as Ed Sheeran, Gabrielle and others. It was preceded by the release of the top-ten single "Wonder" (featuring Sandé), the number one hit "La La La", featuring Sam Smith and "Lifted", another collaboration with Sandé. His debut album peaked at number two in the UK.

Naughty Boy (disambiguation)

Naughty Boy may refer to:

Books

Mo's Mischief, known in Chinese as Naughty Boy Ma Xiaotiao (淘气包马小跳), is a series of children's books written by Chinese author Yang Hongying.

People

Film

EF

EF or ef may refer to:

Computing

Culture

Linguistics

Organizations

Psychology

Science

Efavirenz

Efavirenz (EFV), sold under the brand names Sustiva among others, is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, the United States Department of Health and Human Services Panel on Antiretroviral Guidelines currently recommends the use of efavirenz in combination with tenofovir/emtricitabine (Truvada) as one of the preferred NNRTI-based regimens in adults and adolescents. Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to reduce the risk of HIV infection in people exposed to a significant risk (e.g. needlestick injuries, certain types of unprotected sex etc.).

It is usually taken on an empty stomach at bedtime to reduce neurological and psychiatric adverse effects.

Efavirenz was combined with the HIV medications tenofovir and emtricitabine, all of which are reverse transcriptase inhibitors. This combination of three medications under the brand name Atripla, provides HAART in a single tablet taken once a day.

E2F4

Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene.

Function

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.

Structure

The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids (Asp + Glu), and a tumor suppressor protein association domain which is embedded within the transactivation domain.