RPA

RPA may refer to:

In Information Technology:

In government:

Replication protein A

Replication protein A (RPA) is a protein that binds to single-stranded DNA in eukaryotic cells. During DNA replication, RPA prevents single-stranded DNA (ssDNA) from winding back on itself or from forming secondary structures. This keeps DNA unwound for the polymerase to replicate it. RPA also binds to ssDNA during the initial phase of homologous recombination, an important process in DNA repair and prophase I of meiosis. Hypersensitivity to DNA damaging agents can be caused by mutations in the RPA gene. Like its role in DNA replication, this keeps ssDNA from binding to itself (self-complementizing) so that the resulting nucleoprotein filament can then be bound by Rad51 and its cofactors. RPA also binds to DNA during the Nucleotide Excision Repair process. This binding stabilizes the repair complex during the repair process. A bacterial homolog is called single-strand binding protein (SSB).

Structure

RPA is a heterotrimer, composed of the subunits RPA1 (70kDa subunit), RPA2 (32kDa subunit) and RPA3 (14kDa subunit). The three RPA subunits contain OB-folds (oligonucleotide/oligosaccharide binding).

Representation of the People (Equal Franchise) Act 1928

The Representation of the People (Equal Franchise) Act 1928 was an Act of the Parliament of the United Kingdom. This act expanded on the Representation of the People Act 1918 which had given some women the vote in Parliamentary elections for the first time after World War I. The 1928 Act widened suffrage by giving women electoral equality with men. It gave the vote to all women over 21 years old, regardless of property ownership. Prior to this act only women over 30 who met minimum property qualifications could vote. Similar provision was made for the Parliament of Northern Ireland by the Representation of the People Act (Northern Ireland) 1928 (18 & 19 Geo V, Ch 24 (NI)).

This statute is sometimes known informally as the Fifth Reform Act or the Equal Suffrage Act.

Passing of the act

The act was passed by the Conservative Party without much opposition from other parties. This was unsurprising given that the Liberal Party had been behind most reform in the nineteenth century.

Nasty

Nasty may refer to:

In music:

Other uses:

See also

Nasty (album)

Nasty is a live album released by the funk/R&B group Cameo in 1996. In addition to the live material, two new studio tracks were included: "Come Fly With Me" and the album's title track, both written by Larry Blackmon. The "Mega-Mix" is a remix of the album's live tracks. The new studio tracks on this release were the only newly written material released by the band for the next five albums.

Track listing

Nasty (Pixie Lott song)

"Nasty" is a song by English recording artist Pixie Lott from her self-titled third studio album (2014). It was released on 7 March 2014 as the album's lead single by Mercury Records. The accompanying music video was filmed in November 2013 and directed by Bryan Barber. A second version featured British band The Vamps was released in the same day only in United Kingdom and Ireland.

"Nasty" was previously recorded by American singer Christina Aguilera in collaboration with CeeLo Green for inclusion on the soundtrack to the 2010 film Burlesque, which stars Aguilera and Cher, but it was ultimately scrapped from the official track listing due to legal issues concerning sample clearance.

Background

"Nasty" was previously recorded by several artists, including Christina Aguilera, who recorded the song as a duet with CeeLo Green for her debut film project Burlesque (2010). However, their version did not make the final track listing due to legal issues concerning sample clearance. After Lott's legal team managed to clear all of the song's samples, the singer recorded her own version of the song and released it as the first single from her self-titled third studio album. In an interview with Metro, Lott explained, "A few other singers had recorded it and Christina was one of them so everyone wanted this song. When I heard other singers had done it I thought 'I need to get this!' It was a difficult song to get because there are so many old-school samples on it, like James Brown, that are hard to clear copyright on. But I got it and now it is my new single."

Secretary (title)

Secretary is a title often used in organizations to indicate a person having a certain amount of authority, power, or importance in the organization. The term is derived from the Latin word secernere, "to distinguish" or "to set apart", the passive participle (secretum) meaning "having been set apart", with the eventual connotation of something private or confidential, as with the English word secret. A secretarius was a person, therefore, overseeing business confidentially, usually for a powerful individual (a king, pope, etc.).

The official title of the leader of most Communist and Socialist political parties is the "General Secretary of the Central Committee" or "First Secretary of the Central Committee". When a Communist party is in power, the General Secretary is usually the country's de facto leader (though sometimes this leader also holds state-level positions to monopolize power, such as a presidency or premiership in order to constitute de jure leadership of the state), such as China and Cuba.