SK-1

SK-1 or SK1 may refer to:

Casio SK-1, a small sampling keyboard

Garant 30k SK-1, an East German armored vehicle

Hammond SK1, a modern keyboard

SK-1 spacesuit, an early Russian spacesuit

sK1 (program), a fork of the Skencil vector graphics editor

Sphingosine kinase 1, a protein

This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/SK-1

Sphingosine kinase 1

Sphingosine kinase 1 is an enzyme that in humans is encoded by the SPHK1 gene.

Sphingosine kinase 1 phosphorylates sphingosine to sphingosine-1-phosphate (S1P) SK1 is normally a cytosolic protein but is recruited to membranes rich in phosphatidate (PA), a product of Phospholipase D (PLD)

Sphingosine-1-phosphate (S1P) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1. Various stimuli increase cellular levels of S1P by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of S1P and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor and serum.

Interactions

SPHK1 has been shown to interact with TRAF2.

References

External links

Paugh SW, Kapitonov D, Spiegel S (2007-11-08). "Sphingosine kinase 1". UCSD-Nature Molecule Pages. Signaling Gateway: University of California San Diego (UCSD) and Nature Publishing Group. doi:10.1038/mp.a002219.01. Retrieved 2008-09-15.

This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Sphingosine_kinase_1

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