NUMB (gene)

Protein numb homolog is a protein that in humans is encoded by the NUMB gene.

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.

The protein Numb is coded for by the gene, NUMB, whose mechanism appears to be evolutionarily conserved. Numb has been extensively studied in both invertebrates and mammals, though its function is best understood in Drosophila. Numb plays a crucial role in asymmetrical cell division during development, allowing for differential cell fate specification in the central and peripheral nervous systems. During neurogenesis, Numb localizes to one side of the mother cell such that it is distributed selectively to one daughter cell. This asymmetric division allows a daughter cell containing Numb to acquire a different fate than the other daughter cell.

Gene

A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.

Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term "having a gene" (e.g., "good genes," "hair colour gene") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.

Eugene (given name)

Eugene is a common (masculine) first name that comes from the Greek εὐγενής (eugenēs), "noble", literally "well-born", from εὖ (eu), "well" and γένος (genos), "race, stock, kin".Gene is a common shortened form. The feminine variant is Eugenia or Eugénie.

Male foreign-language variants include:

Notable people

Christianity

Military

Gene (novel)

Gene is a thriller novel by Stel Pavlou (born 1970), published in 2005 in England by Simon & Schuster. It is published in several languages with some title changes. The Italian edition has the title La Conspirazione del Minotauro (The Minotaur Conspiracy). The novel is about a fictional New York detective, James North, who in the process of hunting down a criminal, uncovers a genetics experiment to unlock past lives through genetic memory, therefore achieving a kind of immortality. In so doing North discovers his own origins, that of a soldier from the Trojan War who is reincarnated seven times through history, forced to confront his nemesis each time, all for the loss of his one true love.

Characters

Cyclades (born circa 1300 BC)

Incarnations of Cyclades

Athanatos (born circa 1500 BC)

Incarnations of Athanatos

Numb

Numb may refer to:

Music

Albums

Songs

Numb (Rihanna song)

"Numb" is a song by Barbadian singer Rihanna from her seventh studio album Unapologetic (2012). It features guest vocals by American rapper Eminem, making it the pair's third collaboration since the two official versions of "Love the Way You Lie". Following the album's release, "Numb" charted on multiple charts worldwide including in Canada, the United Kingdom and the United States.

Composition and lyrical interpretation

"Numb" lasts for a duration of 3:25. The song's instrumentation consists of an Egyptian flute riff and "a crashing bombastic beat." "Numb" contains a sample of Kanye West's song "Can't Tell Me Nothing", written by West and Aldrin Davis. The lyric "Let the champagne smash/ Let that man get cash" from "Can't Tell Me Nothing" is the sample used in "Numb". The song's lyrical content is "controversial" as it is about feeling "numb after taking drugs." and a "homage to getting high." Rihanna performs the lines

I don't care Can't tell me nothing I'm impaired

in the first Verse. Eminem "spits" his verse, performing the lines

Numb (Linea 77 album)

Numb is the third studio album from the Italian nu metal band Linea 77.

Track listing