NUDT1
7,8-dihydro-8-oxoguanine triphosphatase is an enzyme that in humans is encoded by the NUDT1 gene.
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
Podcasts:
Fly
by: Nate TaoGot a call
From a friend.
Tried to smile
As I lay in my bed.
All I heard
Where the voices in my head.
Why do you
Have to be
So much more
Then I could hope for me.
Honestly, all I feel is jealously.
And I know that it's wrong
My dreams were at a long
So there's no need to fight this battle every night
Cause I will get there
I have what it takes to survive.
It's over! Glad it's over!
All the doubts and questions in my head.
I'm better off without instead
Now or never, so I just gotta try
To the man I was today I say goodbye.
Tomorrow I will fly, fly, fly.
Watch me fly, fly, fly.
When they talk
When they stare.
It feels just,
Like I'm not even there.
And I say, that I don't really care.
But the truth is that it
Gets to me and it shakes my belief
In myself am what I aim to be
And I know that it's wrong
My dreams were at a long
So there's no need to fight this battle every night
Cause I will get there
I have what it takes to survive.
It's over! Glad it's over!
All the doubts and questions in my head.
I'm better off without instead
Now or never, so I just gotta try
To the man I was today I say goodbye.
And now the finish line
Seems a distant side.
But imma put my eye
On the final prize.
However it longs to takes
I will bend or break, cause this could be, the moment of my life.
It's over! Glad it's over!
All the doubts and questions in my head.
I'm better off without instead
Now or never, so I just gotta try
To the man I was today I say goodbye.
Tomorrow I will fly, fly, fly.
Watch me fly, fly, fly.
Watch me fly, fly, fly.