NT5E
5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (Cluster of Differentiation 73), is an enzyme that in humans is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine.
Function
Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. Rare allelic variants are associated with a syndrome of adult-onset calcification of joints and arteries (CALJA) affecting the iliac, femoral, and tibial arteries reducing circulation in the legs and the joints of the hands and feet causing pain.
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Fly
by: Nate TaoGot a call
From a friend.
Tried to smile
As I lay in my bed.
All I heard
Where the voices in my head.
Why do you
Have to be
So much more
Then I could hope for me.
Honestly, all I feel is jealously.
And I know that it's wrong
My dreams were at a long
So there's no need to fight this battle every night
Cause I will get there
I have what it takes to survive.
It's over! Glad it's over!
All the doubts and questions in my head.
I'm better off without instead
Now or never, so I just gotta try
To the man I was today I say goodbye.
Tomorrow I will fly, fly, fly.
Watch me fly, fly, fly.
When they talk
When they stare.
It feels just,
Like I'm not even there.
And I say, that I don't really care.
But the truth is that it
Gets to me and it shakes my belief
In myself am what I aim to be
And I know that it's wrong
My dreams were at a long
So there's no need to fight this battle every night
Cause I will get there
I have what it takes to survive.
It's over! Glad it's over!
All the doubts and questions in my head.
I'm better off without instead
Now or never, so I just gotta try
To the man I was today I say goodbye.
And now the finish line
Seems a distant side.
But imma put my eye
On the final prize.
However it longs to takes
I will bend or break, cause this could be, the moment of my life.
It's over! Glad it's over!
All the doubts and questions in my head.
I'm better off without instead
Now or never, so I just gotta try
To the man I was today I say goodbye.
Tomorrow I will fly, fly, fly.
Watch me fly, fly, fly.
Watch me fly, fly, fly.