Neuregulin 1
Neuregulin 1 or NRG1 is a protein that in humans is encoded by the NRG1 gene. NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. Neuregulin 1 is produced in numerous isoforms by alternative splicing, which allows it to perform a wide variety of functions. It is essential for the normal development of the nervous system and the heart.
Structure
Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specific and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through their displayed interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.
Podcasts:
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by U2
New York
by: U2In New York freedom looks like
Too many choices
In New York I found a friend
To drown out the other voices
Voices on the cell phone
Voices from home
Voices of the hard sell
Voices down the stairwell
In New York
Just got a place in New York
In New York summers get hot
Well into the hundreds
You can't walk around the block
Without a change of clothin'
Hot as a hairdryer in your face
Hot as a handbag and a can of mace
New York
I just got a place in New York
New York
(New York)
New York
In New York you can forget
Forget how to sit still
Tell yourself you will stay in
But it's down to Alphaville
New York
New York, New York
New York, New York
New York
(Aoo)
The Irish have been comin' here for years
Feel like they own the place
They got the airport, city hall, asphalt, dance floor
They even got the police
Irish, Italians, Jews and Hispanics
Religious nuts, political fanatics in the stew
Happily, not like me and you
That's where I lost you, New York
New York, New York
New York
New York, New York
New York
Aoo ooo
New York
Aoo ooo
In New York I lost it all
To you and your vices
Still I'm stayin' on to figure out
My mid life crisis
I hit an iceberg in my life
You know I'm still afloat
You lose your balance, lose your wife
In the queue for the lifeboat
You got to put the women and children first
But you've got an unquenchable thirst for New York
New York
New York
New York, New York
In the stillness of the evening
When the sun has had it's day
I heard your voice whisperin'
Come away now
New, New York
New, New York
Aoo ooo