Delucemine
Delucemine (NPS-1506) is a drug which acts as an NMDA antagonist and a serotonin reuptake inhibitor, and has neuroprotective effects. It was originally investigated for the treatment of stroke and in 2004 was studied as a potential antidepressant.
Origin
The basic structure of Delucemine was based on argiotoxin 636, a NMDA antagonist isolated from the venom of the Araneid Argiope aurantia.
See also
AD-1211
Budipine
Diphenidine
Ephenidine
Fluorolintane
Lanicemine
Methoxphenidine
MT-45
Remacemide
References
↑ Mueller AL, Artman LD, Balandrin MF, Brady E, Chien Y, Delmar EG, George K, Kierstead A, Marriott TB, Moe ST, Newman MK, Raszkiewicz JL, Sanguinetti EL, van Wagenen BC, Wells D. (December 1999). "NPS 1506, a novel NMDA receptor antagonist and neuroprotectant. Review of preclinical and clinical studies.". Annals of the New York Academy of Sciences 890: 450–457. doi:10.1111/j.1749-6632.1999.tb08023.x. PMID 10668449.
↑ Matthew J. Leoni, Xiao-Han Chen, Alan L. Mueller, Jessica Cheney, Tracy K. McIntosh, Douglas H. Smith (December 2000). "NPS 1506 attenuates cognitive dysfunction and hippocampal neuron death following brain trauma in the rat.". Experimental Neurology 166 (2): 442–449. doi:10.1006/exnr.2000.7513. PMID 11085909.
