NOD2
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) also known as caspase recruitment domain-containing protein 15 (CARD15) or inflammatory bowel disease protein 1 (IBD1) is a protein that in humans is encoded by the NOD2 gene located on chromosome 16. NOD2 plays an important role in the immune system. It recognizes bacterial molecules (peptidoglycans) and stimulates an immune reaction.
NOD2 is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants and recognizes molecules containing the specific structure called muramyl dipeptide (MDP) that is found in certain bacteria.
Structure
The C-terminal portion of the protein contains a leucine-rich repeat domain that is known to play a role in protein–protein interactions. The middle part of the protein is characterized by a NOD domain involved in protein self-oligomerization. The N-terminal portion contains two CARD domains known to play a role in apoptosis and NF-κB activation pathways.
Podcasts:
Fly
by: Nate TaoGot a call
From a friend.
Tried to smile
As I lay in my bed.
All I heard
Where the voices in my head.
Why do you
Have to be
So much more
Then I could hope for me.
Honestly, all I feel is jealously.
And I know that it's wrong
My dreams were at a long
So there's no need to fight this battle every night
Cause I will get there
I have what it takes to survive.
It's over! Glad it's over!
All the doubts and questions in my head.
I'm better off without instead
Now or never, so I just gotta try
To the man I was today I say goodbye.
Tomorrow I will fly, fly, fly.
Watch me fly, fly, fly.
When they talk
When they stare.
It feels just,
Like I'm not even there.
And I say, that I don't really care.
But the truth is that it
Gets to me and it shakes my belief
In myself am what I aim to be
And I know that it's wrong
My dreams were at a long
So there's no need to fight this battle every night
Cause I will get there
I have what it takes to survive.
It's over! Glad it's over!
All the doubts and questions in my head.
I'm better off without instead
Now or never, so I just gotta try
To the man I was today I say goodbye.
And now the finish line
Seems a distant side.
But imma put my eye
On the final prize.
However it longs to takes
I will bend or break, cause this could be, the moment of my life.
It's over! Glad it's over!
All the doubts and questions in my head.
I'm better off without instead
Now or never, so I just gotta try
To the man I was today I say goodbye.
Tomorrow I will fly, fly, fly.
Watch me fly, fly, fly.
Watch me fly, fly, fly.