NNE1

NNE1 (also known as NNEI, MN-24 and AM-6527) is an indole-based synthetic cannabinoid, representing a molecular hybrid of APICA and JWH-018. It was invented by Abbott and has a CB₁ receptor pEC₅₀ of 8.9 (i.e. EC₅₀ of approximately 1nM) with around 80x selectivity over the related CB₂ receptor. It is suspected that metabolic hydrolysis of the amide group of NNE1 may release 1-naphthylamine, a known carcinogen, given the known metabolic liberation (and presence as an impurity) of amantadine in the related compound APINACA, and NNE1 was banned in New Zealand in 2012 as a temporary class drug to stop it being used as an ingredient in then-legal synthetic cannabis products. NNE1 was subsequently found to be responsible for the death of a man in Japan in 2014.

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Points of the compass

The points of the compass are points on a compass, specifically on the compass rose, marking divisions of the four cardinal directions: North, South, East, West. The number of points may be only the 4 cardinal points, or the 8 principal points adding the intercardinal (or ordinal) directions northeast (NE), southeast (SE), southwest (SW), and northwest (NW). In meteorological usage further intermediate points are added to give the sixteen points of a wind compass. Finally, at the most complete in European tradition, are found the full thirty-two points of the mariner's compass. In ancient China 24 points of the compass were used.

In the mariner's exercise of boxing the compass, all thirty-two points of the compass are named in clockwise order. The names of intermediate points are formed by the initials of the cardinal directions and their intermediate ordinal directions, and are very handy to refer to a heading (or course or azimuth) in a general or colloquial fashion, without having to resort to computing or recalling degrees. For most applications, the minor points have been superseded by degrees measured clockwise from North.