NKG2D
NKG2D is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors. NKG2D is encoded by KLRK1 gene which is located in the NK-gene complex (NKC) situated on chromosome 6 in mice and chromosome 12 in humans. In mice, it is expressed by NK cells, NK1.1+ T cells, γδ T cells, activated CD8+ αβ T cells and activated macrophages. In humans, it is expressed by NK cells, γδ T cells and CD8+ αβ T cells. NKG2D recognizes induced-self proteins from MIC and RAET1/ULBP families which appear on the surface of stressed, malignant transformed, and infected cells.
Structure
Human NKG2D receptor complex assembles into a hexameric structure. NKG2D itself forms a homodimer whose ectodomains serve for ligand binding. Each NKG2D monomer is associated with DAP10 dimer. This association is maintained by ionic interaction of a positively charged arginine present in a transmembrane segment of NKG2D and negatively charged aspartic acids within both transmembrane regions of DAP10 dimer.DAP10 functions as an adaptor protein and transduces the signal after the ligand binding by recruiting the p85 subunit of PI3K and Grb2-Vav1 complex which are responsible for subsequent downstream events.
Podcasts:
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by Nick Scotti
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by Nick Scotti
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by Nick Scotti
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by Nick Scotti
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by Nick Scotti
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by Nick Scotti
This Could Take All Night
by: Nick ScottiWritten by Diane Warren
I've got something I've been keeping inside
And I wanna share my secret
Want to share it tonight
And the moon outside is saying that the moment is right, right now
I've got a message coming straight from the heart
And I got so much I wanna say
Hardly know where to start
Gonna wait 'til we're together all alone in the dark, oh
I'm gonna hold you
And when the time is right
I'm gonna show you just what's been on my mind
Waited for so long, it's so strong
I just can't hold back
You know that
CHORUS:
This could take all night
From sundown up to sunlight
And we won't stop until the daylight
'Cause this could take all night
Yeah this could take all night
There's no hurry we can take it slow
I'll take the time to show you everything you need to know
You'll see everything much better with the lights down low
Oh I'm gonna hold you
And when the time is right
I'm gonna show you just what's been on my mind
Waited for so long, it's so strong
I just can't hold back
You know that
CHORUS
Waited for so long, it's so strong
I just can't hold back
You know that
We got the whole night baby
To hold on tight
Let's take a long ride
We got the time
CHORUS