NISCH
Nischarin is a protein that in humans is encoded by the NISCH gene.
Function
This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation.
Clinical significance
Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin.
Interactions
NISCH has been shown to interact with IRS4.
See also
References
Podcasts:
-
by Nishay
-
by Nishay
-
by Nishay
-
by Nishay
-
by Nishay
-
by Notch
-
by Notch
-
by Notch
-
by Notch
-
by Notch
-
by Notch
-
by Notch
-
by Notch
-
by Notch
-
by Neesha
-
by Neesha
-
by Nyche
-
by Na'shay
-
by Nisha
-
by Na'shay
-
by Na'shay
-
by Na'shay
-
by Nisha
-
by Na'shay
-
by Na'shay
-
by Na'shay
-
by Na'shay
-
by Na'shay
-
by Na'shay
-
by Na'shay
-
by Na'shay
-
by Na'shay
-
by Na'shay
Let's Talk About It
by: NishayThe way you watching me
My feeling left when you grew another part of me
And I'm just saying what's really deep inside of me
The way I feel
I feel so real
Really I'm just tryna contemplate the night
Wrapped on my mind and holding me so tight
Climbing my emotions and it's shining bright
The questions I wont ask
I wont ask you
Would you respect me
Don't leave me home
Would you really admit that your mine alone
Would you answer things I wanna know
Oh boy I wanna know, don't lie about it (please don't like about it)
Would ja would ja would ja really lie to me (would you lie to me boy)
I feel connected this here must not stop (I feel connected)
If you can't talk about what's really gonna hold me up(oh)
Oh boy Lets talk about it (lets talk about it)
Would ja would ja would ja really lie to me (woulja really lie to me)
(Boy--verse 2)
It's like I don't want to change
If you knew it would you really still had feel the same
These three words "I love you" would you really change
Lets talk about it... let(skip)
Would you hurt me, desert me, do wrong to me,
Take for granted boy, baby don't encourage we, let's talk about the change
Ooh I got questions for you...
(I got questions for you)
Would you respect me
Don't leave me home
Would you really admit that your mine alone
Would you answer things I wanna know
Oh boy I wanna know, don't lie about it (please don't like about it)
Would ja would ja would ja really lie to me (would you lie to me boy oh)
I feel connected this here must not stop (I feel connected)
If you can't talk about what's really gonna hold me up(oh)
Oh boy Lets talk about it (lets talk about it)
Would ja would ja would ja really lie to me (woulja really lie to me)
Oh... (tttalk about it)
Would you respect me
Don't leave me home
Would you really admit that your mine alone
Would you answer things I wanna know
Oh boy I wanna know, don't lie about it (please don't like about it)
Would ja would ja would ja really lie to me (would you lie to me boy oh)
I feel connected this here must not stop (I feel connected)
If you can't talk about what's really gonna hold me up(oh)
Oh boy Lets talk about it (lets talk about it)
Latest News for: nisch
- 1