Non-imprinted in Prader-Willi/Angelman syndrome region protein 1 is a protein that in humans is encoded by the NIPA1 gene.This gene encodes a potential transmembrane protein which functions either as a receptor or transporter molecule, possibly as a magnesium transporter. This protein is thought to play a role in nervous system development and maintenance. Alternative splice variants have been described, but their biological nature has not been determined. Mutations in this gene have been associated with the human genetic disease autosomal dominant spastic paraplegia 6.
Model organisms have been used in the study of NIPA1 function. A conditional knockout mouse line, called Nipa1tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on mutant mice but no significant abnormalities were observed.
Standing in a shadow of true love Wishing that the
other side would really be gone
Hoping for the worst that would be best for me Hoping
that the other side would never see
That I´m Fallen to gutter of long dark road Running to
harbour for long gone boat
Buried in six feet of cold hard soil Trying to keep it
real
When I´m with you Im here and everywhere
But my heart is somewhere else I will try to make it
last
Heartache will soon be past Pick your number next in
line
Maybe now I will be fine NOT
Waiting for the bullet to split my head Maybe then I
would be fine when buried and dead
Nothing really changes the way I feel It´s like now I
don´t have soul, but my body will stay
And I´m fallen to gutter of long dark road Running to
harbour for long gone boat
Buried in six feet of cold hard soil Trying to keep it
real
When I´m with you I´m here and everywhere
But my heart is somewhere else I will try to make it
last
Heartache will soon be past Pick your number next in
line
Maybe now I will be fine NOT
And I´m fallen to gutter of long dark road Running to
harbour for long gone boat
Buried in six feet of cold hard soil Trying to keep it
real
When I´m with you I´m here and everywhere
But my heart is somewhere else I will try to make it
last
Heartache will soon be past Pick your number next in
line