Niacin receptor 1, also known as NIACR1 or GPR109A, is a protein which in humans is encoded by the NIACR1 gene.
NIACR1 is a high-affinity Gi/Go-coupled G protein-coupled receptor (GPCR) for nicotinic acid (niacin), and is a member of the nicotinic acid receptor family of GPCRs (the other identified member being Niacin receptor 2, also known as GPR109B). Butyrate is also another common ligand (full agonist) of NIACR1.
Niacin receptor 1 is an important biomolecular target of niacin which is a widely prescribed drug for the treatment of dyslipidemia and to increase HDL cholesterol but whose therapeutic use is limited by flushing. In NIACR1 knockout mice, the effects of niacin on both lipids and flushing is eliminated. Furthermore, in arrestin beta 1 knockout mice, niacin's effect on flushing is greatly reduced while the lipid modifying effects are maintained.
The precise mechanism of action of niacin therapeutic effects has not been fully elucidated, but appears to work in part through activation of NIACR1 which reduces the levels of intracellular cAMP thereby inhibiting lipolysis in adipocytes. In contrast, the flushing effect is due to NIACR1 activation of ERK 1/2 MAP kinase mediated by arrestin beta 1. Activation of MAP kinase in turn causes release of prostaglandin D2 from Langerhans cells in the skin.
Niacin receptor 2, also known as NIACR2 or GPR109B, is a protein which in humans is encoded by the NIACR2 gene.
GPR109B is a low affinity receptor for nicotinic acid (niacin) and is a member of the nicotinic acid receptor family of G protein-coupled receptors (the other identified member being GPR109A).
GPR109B is a Gi /Go protein-coupled receptor with low affinity for nicotinic acid.
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And from the womb to the tomb
Spray some perfume on your cocoon
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I'm being pampered by two sluts with tits
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All over nipples your panties have been dampened
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You sound like a kitten purrin,
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[Hook]
Throw your head back as I fuck you to this track
Throw your head back as I fuck you to the track
Throw your head back as I fuck you to this track
Throw your head back as I fuck you to the track
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When you getting your ass licked
Invading your body like your plastic
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Dirty questions and nasty answers
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Necro's written all over your breast with body paint
I've got a little cock
Thats something big for all of them pimples in Little Rock
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can't handle that much pleasure
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Of all the times you were bent,
over recieving the cock rock like cement
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by stretching your tight pussy to the limit
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Believe it or Not, cause it'll slice up a beaver like a cleaver or mop?
Or a shot of scum in your twat of any diva thats hot
*Get undressed*
[Hook]
Throw your head back as I fuck you to the track
Throw your head back as I fuck you to the track
Throw your head back as I fuck you to the track
Throw your head back slut