Neurogenin-3
Neurogenin-3 is a protein that in humans is encoded by the NEUROG3 gene.
Neurogenin-3 is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine. It belongs to a family of basic helix-loop-helix (bHLH) transcription factors involved in the determination of neural precursor cells in the neuroectoderm.
Neurogenin 3 (NGN3) is expressed by 2-10% of acinar and duct cells in the histologically normal adult human pancreas. NGN3+ cells isolated from cultured exocrine tissue by coexpressed cell surface glycoprotein CD133 have a transcriptome consistent with exocrine dedifferentiation, a phenotype that resembles endocrine progenitor cells during development, and a capacity for endocrine differentiation in vitro. Human and rodent exocrine cells have been reprogrammed into cells with an islet cell-like phenotype following direct expression of NGN3 or manipulation that leads to its expression.
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Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Podcasts:
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by U2
New York
by: U2In New York freedom looks like
Too many choices
In New York I found a friend
To drown out the other voices
Voices on the cell phone
Voices from home
Voices of the hard sell
Voices down the stairwell
In New York
Just got a place in New York
In New York summers get hot
Well into the hundreds
You can't walk around the block
Without a change of clothin'
Hot as a hairdryer in your face
Hot as a handbag and a can of mace
New York
I just got a place in New York
New York
(New York)
New York
In New York you can forget
Forget how to sit still
Tell yourself you will stay in
But it's down to Alphaville
New York
New York, New York
New York, New York
New York
(Aoo)
The Irish have been comin' here for years
Feel like they own the place
They got the airport, city hall, asphalt, dance floor
They even got the police
Irish, Italians, Jews and Hispanics
Religious nuts, political fanatics in the stew
Happily, not like me and you
That's where I lost you, New York
New York, New York
New York
New York, New York
New York
Aoo ooo
New York
Aoo ooo
In New York I lost it all
To you and your vices
Still I'm stayin' on to figure out
My mid life crisis
I hit an iceberg in my life
You know I'm still afloat
You lose your balance, lose your wife
In the queue for the lifeboat
You got to put the women and children first
But you've got an unquenchable thirst for New York
New York
New York
New York, New York
In the stillness of the evening
When the sun has had it's day
I heard your voice whisperin'
Come away now
New, New York
New, New York
Aoo ooo