NEUROD1

Neurogenic differentiation 1 (NeuroD1), also called β2, is a transcription factor of the NeuroD-type. It is encoded by the human gene NEUROD1.

It is a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus.

Interactions

NEUROD1 has been shown to interact with MAP3K10,MAFA and Cyclin D1.

References

Further reading

External links

  • NEUROD1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
  • This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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    by: Eric Carmen

    (Eric Carmen)
    Lovers come and lovers go
    But it's never twice the same
    Happiness is hard to show
    When you're numb to all the pain
    And I've been floatin' 'round
    Like an old newspaper
    Blowin' down some windy street
    Feeling so alone and incomplete
    But there's nowhere to hide
    Where the night can't find me
    Where the light of the sun can't blind me
    Like the light in a woman's eyes
    There's nowhere to hide
    From the dream that drives me
    Like a fire burning deep inside me
    Oh, I know she'll be there tonight
    Can the future be foretold
    In a faded photograph
    Can a dream be bought and sold
    Well, I guess I have to laugh
    Sippin' on a scotch and soda
    A shadow in the corner booth
    So philosophic and drunk on grown-up truth
    But there's nowhere to hide
    Where the night can't find me
    Where the light of the sun can't blind me
    Like the light in a woman's eyes
    There's nowhere to hide
    From the dream that drives me
    Like a fire burning deep inside me
    Oh, I know she'll be there tonight
    Half-forgotten fragments
    Of a high school dance
    In the dead white hours of winter
    When we loved so hard
    That we thought it would never end
    Tryin' to remember
    How it used to feel
    When a kiss was something special
    And I wonder now
    Will it ever be again
    But there's nowhere to hide
    Where the night can't find me
    Where the light of the sun can't blind me
    Like the light in a woman's eyes
    There's nowhere to hide
    From the dream that drives me
    Like a fire burning deep inside me
    Oh, I know she'll be there tonight
    Lovers come and lovers go
    But it's never twice the same
    Happiness is hard to show
    When you're numb to all the pain
    And I've been floatin' round
    Like an old newspaper
    Blowin' down some windy street
    Feeling so alone and incomplete
    But there's nowhere to hide
    Where the night can't find me
    Where the light of the sun can't blind me
    Like the light in a woman's eyes
    There's nowhere to hide
    From the dream that drives me
    Like a fire burning deep inside me
    Oh, I know she'll be there tonight




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