NEDD9
Neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) is a protein that in humans is encoded by the NEDD9 gene. NEDD-9 is also known as enhancer of filamentation 1 (EF1), CRK-associated substrate-related protein (CAS-L), and Cas scaffolding protein family member 2 (CASS2). An important paralog of this gene is BCAR1.
Discovery
In 1992, Kumar, et al., first described a sequence tag corresponding to the NEDD9 3′ untranslated region based on the cloning of a group of genes predominantly expressed in the brain of embryonic, but not adult mice, a group of genes designated neural precursor cell expressed, developmentally down-regulated. In 1996, two groups independently described the complete sequence of the NEDD9 gene, and provided initial functional analysis of NEDD9 protein. Law et al. overexpressed a human cDNA library in S. cerevisiae, and screened for genes that simultaneously affected cell cycle and cell polarity controls, inducing a filamentous yeast budding phenotype, and thus identified the HEF1 protein (Human Enhancer of Filamentation 1). This study identified HEF1/NEDD9 as an interactive partner for focal adhesion kinase (FAK), connecting it to integrin signaling. Separately, Minegishi et al. cloned the gene encoding a protein hyperphosphorylated following ligation of β1-integrins in T cells and hypothesized to play a role in the process of T cell costimulation, designating this gene Cas-L (Crk-associated substrate-related protein, Lymphocyte type).
Podcasts:
Fly
by: Nate TaoGot a call
From a friend.
Tried to smile
As I lay in my bed.
All I heard
Where the voices in my head.
Why do you
Have to be
So much more
Then I could hope for me.
Honestly, all I feel is jealously.
And I know that it's wrong
My dreams were at a long
So there's no need to fight this battle every night
Cause I will get there
I have what it takes to survive.
It's over! Glad it's over!
All the doubts and questions in my head.
I'm better off without instead
Now or never, so I just gotta try
To the man I was today I say goodbye.
Tomorrow I will fly, fly, fly.
Watch me fly, fly, fly.
When they talk
When they stare.
It feels just,
Like I'm not even there.
And I say, that I don't really care.
But the truth is that it
Gets to me and it shakes my belief
In myself am what I aim to be
And I know that it's wrong
My dreams were at a long
So there's no need to fight this battle every night
Cause I will get there
I have what it takes to survive.
It's over! Glad it's over!
All the doubts and questions in my head.
I'm better off without instead
Now or never, so I just gotta try
To the man I was today I say goodbye.
And now the finish line
Seems a distant side.
But imma put my eye
On the final prize.
However it longs to takes
I will bend or break, cause this could be, the moment of my life.
It's over! Glad it's over!
All the doubts and questions in my head.
I'm better off without instead
Now or never, so I just gotta try
To the man I was today I say goodbye.
Tomorrow I will fly, fly, fly.
Watch me fly, fly, fly.
Watch me fly, fly, fly.