NAPA (gene)

N-ethylmaleimide-sensitive factor Attachment Protein Alpha, also known as SNAP-α, is a protein that is involved in the intra-cellular trafficking and fusing of vesicles to target membranes in cells.

Function

The 'SNARE hypothesis' is a model explaining the process of docking and fusion of vesicles to their target membranes. According to this model, membrane proteins from the vesicle (v-SNAREs) and proteins from the target membrane (t-SNAREs) govern the specificity of vesicle targeting and docking through mutual recognition. Once the 2 classes of SNAREs bind to each other, they form a complex that recruits the general elements of the fusion apparatus, namely NSF (N-ethylmaleimide-sensitive factor) and SNAPs (soluble NSF-attachment proteins), to the site of membrane fusion, thereby forming the 20S fusion complex. Alpha- and gamma-SNAP are found in a wide range of tissues and act synergistically in intra-Golgi transport. The sequence of the predicted 295-amino acid human protein encoded by NAPA shares 37%, 60%, and 67% identity with the sequences of yeast, Drosophila, and squid alpha-SNAP, respectively. Platelets contain some of the same proteins, including NSF, p115/TAP, alpha-SNAP (this protein), gamma-SNAP, and the t-SNAREs syntaxin-2 and syntaxin-4, that are used in many vesicular transport processes in other cell types. Platelet exocytosis uses a molecular mechanism similar to that used by other secretory cells, such as neurons, although the proteins used by the platelet and their modes of regulation may be quite different.

Eugene (given name)

Eugene is a common (masculine) first name that comes from the Greek εὐγενής (eugenēs), "noble", literally "well-born", from εὖ (eu), "well" and γένος (genos), "race, stock, kin".Gene is a common shortened form. The feminine variant is Eugenia or Eugénie.

Male foreign-language variants include:

Notable people

Christianity

Military

Gene (novel)

Gene is a thriller novel by Stel Pavlou (born 1970), published in 2005 in England by Simon & Schuster. It is published in several languages with some title changes. The Italian edition has the title La Conspirazione del Minotauro (The Minotaur Conspiracy). The novel is about a fictional New York detective, James North, who in the process of hunting down a criminal, uncovers a genetics experiment to unlock past lives through genetic memory, therefore achieving a kind of immortality. In so doing North discovers his own origins, that of a soldier from the Trojan War who is reincarnated seven times through history, forced to confront his nemesis each time, all for the loss of his one true love.

Characters

Cyclades (born circa 1300 BC)

Incarnations of Cyclades

Athanatos (born circa 1500 BC)

Incarnations of Athanatos

Gene (disambiguation)

A gene is a chemical structure effecting biological inheritance.

Gene also may refer to:

Given names:

Printed works:

Fictional characters:

Other:

See also

Napa

Napa may refer to:

Places:

People:

Other uses:

NAPA may stand for:

Napa, California

The city of Napa is the county seat of Napa County, California, United States. It is the principal city of the Napa County Metropolitan Statistical Area, which encompasses Napa County. As of the 2010 census, the city had a total population of 76,915. Napa was incorporated as a city in 1872.

History

Early history

The name "Napa" was probably derived from the name given to a southern Nappan village whose native people shared the area with elk, deer, grizzlies and cougars for many centuries, according to Napa historian Kami Santiago. At the time of the first recorded exploration into Napa Valley in 1823, the majority of the inhabitants consisted of Native American Indians. Padre José Altimira, founder of Mission San Francisco Solano in Sonoma, led the expedition. Spanish priests converted some natives; the rest were attacked and dispersed by Spanish soldiers. American farmers began arriving in the 1830s.

Before California was granted statehood in 1849, the Napa Valley was in the Territory of California's District of Sonoma. In 1850 when counties were first organized, Napa became one of the original counties of California. At the time, its boundaries also included Lake County to the north. By this time, the indigenous people were either working as field laborers or living in small bands in the hills surrounding the valley. Tensions between the white settlers and Native Americans broke into war in 1850, with a white man's death resulting in soldiers hunting down and killing all the natives they could find, driving the remainder north toward Clear Lake. In 1851, the first courthouse was erected. By 1870, the Native American population consisted of only a few laborers and servants working for the white settlers.

1999 NAPA 500

The 1999 NAPA 500 was a NASCAR Winston Cup Series racing event held on November 21, 1999, at Atlanta Motor Speedway in the American community of Hampton, Georgia.

Summary

Out of the 49 drivers who were on the entry list, only 43 drivers managed to make the race. Two of the more notable drivers who did not qualify were Darrell Waltrip and Morgan Shepherd. There were numerous accidents causing a series of yellow flags. Each green flag run was 30 laps while more than 16% of the race was run under a caution flag.

Todd Bodine was the last-place finisher of this 325-lap event that lasted for a duration of three and a half hours. Kevin Lepage was the lucky pole position winner with his solo qualifying speed of 193.731 miles per hour or 311.780 kilometres per hour. A live audience of 165,000 NASCAR enthusiasts came to see 38 different lead changes along with eight cautions lasting 53 laps. The average speed of the race was clocked at 137.932 miles per hour (221.980 km/h); with Bobby Labonte having a 2.5 second edge over Dale Jarrett. In addition, the pole position was Kevin Lepage's for the only time in his NASCAR career.