Neurogenic locus notch homolog protein 4

Neurogenic locus notch homolog 4 also known as notch 4 is a protein that in humans is encoded by the NOTCH4 gene located on chromosome 6.

Gene

An alternative splice variant of the NOTCH4 gene has been described, but its biological significance has not been determined.

Structure

The neurogenic locus notch homolog 4 protein is a member of the Notch family. Members of this type 1 transmembrane protein family share structural characteristics. These include an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain that consists of multiple, but different, domain types.

Function

Notch protein family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling pathway is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells

In Drosophilia, notch interacts with its cell-bound ligands (delta and serrate), and establishes an intercellular signaling pathway that then plays a key role in development. Homologues of the notch-ligands have also been identified in humans, but precise interactions between these ligands and the human notch homologues remain to be determined. The notch protein is cleaved in the trans-Golgi network, and then presented on the cell surface as a heterodimer. The protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal, and hepatic development.

Mós

Mós may refer to the following places in Portugal:

Metre per second

Metre per second (U.S. spelling: meter per second) is an SI derived unit of both speed (scalar) and velocity (vector quantity which specifies both magnitude and a specific direction), defined by distance in metres divided by time in seconds.

The SI unit symbols are m·s⁻¹, m s⁻¹, m/s, or m/s, sometimes (unofficially) abbreviated as "mps". Where metres per second are several orders of magnitude too slow to be convenient, such as in astronomical measurements, velocities may be given in kilometres per second, where 1 km/s is 1000 metres per second, sometimes unofficially abbreviated as "kps".

Conversions

1 m/s is equivalent to:

1 foot per second = 0.3048 m/s (exactly)

1 mile per hour = 0.44704 m/s (exactly)

1 km/h = 0.27 m/s (exactly)

1 kilometre per second is equivalent to:

Relation to other measures

The benz, named in honour of Karl Benz, has been proposed as a name for one metre per second. Although it has seen some support as a practical unit, primarily from German sources, it was rejected as the SI unit of velocity and has not seen widespread use or acceptance.

Marks & Spencer

Marks and Spencer plc (also known as M&S) is a major British multinational retailer headquartered in the City of Westminster, London. It specialises in the selling of clothing, home products and luxury food products. M&S was founded in 1884 by Michael Marks and Thomas Spencer in Leeds.

In 1998, the company became the first British retailer to make a pre-tax profit of over £1 billion, although subsequently it went into a sudden slump, which took the company, its shareholders, who included hundreds of thousands of small investors, and nearly all retail analysts and business journalists, by surprise. In November 2009, it was announced that Marc Bolland, formerly of Morrisons, would take over as chief executive from executive chairman Stuart Rose in early 2010; Rose remained in the role of non-executive chairman until he was replaced by Robert Swannell in January 2011.

It is listed on the London Stock Exchange and is a constituent of the FTSE 100 Index.

History

Establishment

The company was founded by a partnership between Michael Marks, a Polish Jew from Słonim (Marks was born into a Polish-Jewish family, a Polish refugee living in the Russian Empire, now in Belarus), and Thomas Spencer, a cashier from the English market town of Skipton in North Yorkshire. On his arrival in England, Marks worked for a company in Leeds, called Barran, which employed refugees (see Sir John Barran, 1st Baronet). In 1884 he met Isaac Jowitt Dewhirst while looking for work. Dewhirst lent Marks £5 which he used to establish his Penny Bazaar on Kirkgate Market, in Leeds. Dewhirst also taught him a little English. Dewhirst's cashier was Tom Spencer, an excellent bookkeeper, whose lively and intelligent second wife, Agnes, helped improve Marks' English. In 1894, when Marks acquired a permanent stall in Leeds' covered market, he invited Spencer to become his partner.