Mystic Arcana is a 2007 Marvel Comics storyline published as a series of four one-shot titles. Each book in the series contains an individual main story followed by a back-up story with a plot that continues through all four books. The main story in each book focuses upon a different fictional character, each of whom in previous Marvel publications have had associations with magic. The four characters featured are Magik, the Black Knight, the Scarlet Witch, and Sister Grimm. Artist Marko Djurdjevic illustrated the cover for each issue.
Prior to the release of the series, Marvel.com reporter Jim Beard reported that "Mystic Arcana" would be in the same vein as "the wild and woolly genre revitalization, Annihilation." As part of his report Beard interviewed Mystic Arcana's editor Mark Paniccia who explained:
When the "Mystic Arcana" series was introduced at the 2007 New York Comic Convention in New York City at the Marvel Comics "Cup 'O Joe" panel, Marvel editor-in-chief Joe Quesada announced that the series would be published under the creative control of Tarot deck artist David Sexton.