Myofibril
A myofibril (also known as a muscle fibril) is a basic rod-like unit of a muscle cell. Muscles are composed of tubular cells called myocytes, known as muscle fibers in striated muscle, and these cells in turn contain many chains of myofibrils. They are created during embryonic development in a process known as myogenesis.
Myofibrils are composed of long proteins including actin, myosin, and titin, and other proteins that hold them together. These proteins are organized into thick and thin filaments called myofilaments, which repeat along the length of the myofibril in sections called sarcomeres. Muscles contract by sliding the thick (myosin) and thin (actin) filaments along each other.
Structure
The filaments of myofibrils, myofilaments, consist of two types, thick and thin:
Thin filaments consist primarily of the protein actin, coiled with nebulin filaments. Actin, when polymerized into filaments, forms the "ladder" along which the myosin filaments "climb" to generate motion
Thick filaments consist primarily of the protein myosin, held in place by titin filaments. Myosin is responsible for force generation. It is composed of a globular head with both ATP and actin binding sites, and a long tail involved in its polymerization into myosin filaments.