TRP

TRP may refer to:

TYRP1

Tyrosinase-related protein 1, also known as TYRP1, is an enzyme which in humans is encoded by the TYRP1 gene.

Function

Tyrp1 is a melanocyte-specific gene product involved in melanin synthesis. While mouse Tyrp1 possesses dihydroxyindole carboxylic acid oxidase activity, the function in human melanocytes is less clear. In addition to its role in melanin synthesis, Tyrp1 is involved in stabilizing of tyrosinase protein and modulating its catalytic activity. Tyrp1 is also involved in maintenance of melanosome structure and affects melanocyte proliferation and melanocyte cell death.

Clinical significance

Mutations in the mouse Tyrp1 gene are associated with brown pelage and in the human TYRP1 gene with oculocutaneous albinism type 3 (OCA3). An allele of TYRP1 common in Solomon Islanders results in blond hair. Although the phenotype is similar to Northern European blond hair, this allele is not found in Europeans.

Regulation

The expression of TYRP1 is regulated by the microphthalmia-associated transcription factor (MITF).

Dopachrome tautomerase

Dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2), also known as DCT, is a human gene. Its expression is regulated by the microphthalmia-associated transcription factor (MITF).

See also

References

Further reading

Bike

Bike may refer to:

Places

People

Vehicles

Art, entertainment, and media

Brands and enterprises

See also

Generic top-level domain

Generic top-level domains (gTLDs) are one of the categories of top-level domains (TLDs) maintained by the Internet Assigned Numbers Authority (IANA) for use in the Domain Name System of the Internet. A top-level domain is the last label of every fully qualified domain name. They are called generic for historic reasons; initially, they were contrasted with country-specific TLDs in RFC 920.

The core group of generic top-level domains consists of the com, info, net, and org domains. In addition, the domains biz, name, and pro are also considered generic; however, these are designated as restricted, because registrations within them require proof of eligibility within the guidelines set for each.

Historically, the group of generic top-level domains included domains, created in the early development of the domain name system, that are now sponsored by designated agencies or organizations and are restricted to specific types of registrants. Thus, domains edu, gov, int, and mil are now considered sponsored top-level domains, much like the themed top-level domains (e.g., jobs). The entire group of domains that do not have a geographic or country designation (see country-code top-level domain) is still often referred to by the term generic TLDs.

Bike (song)

"Bike" is a song by British rock band Pink Floyd, featured on their 1967 debut album, The Piper at the Gates of Dawn.

Information

In the song, Syd Barrett's lyrical subject shows a girl his bike (which he borrowed), a cloak, a homeless, aging mouse that he calls Gerald, and a clan of gingerbread men—because she "fits in with [his] world." With each repetition of the chorus, a sudden percussive noise is heard similar to the firing of two gunshots. Towards the end of the song, he offers to take her into a "room of musical tunes". The final verse is followed by an instrumental section that is a piece of musique concrète: a noisy collage of oscillators, clocks, gongs, bells, a violin, and other sounds edited with tape techniques, apparently the "other room" spoken of in the song and giving the impression of the turning gears of a bicycle. The ending of the song fades out with a tape loop of the band members laughing reversed and played at double speed. The song was written for Barrett's then girlfriend, Jenny Spires. She is also mentioned as "Jennifer Gentle" in the song "Lucifer Sam", which is also on The Piper at the Gates of Dawn.