In biology, a mutation is a permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements. Mutations result from damage to DNA which is not repaired, errors in the process of replication, or from the insertion or deletion of segments of DNA by mobile genetic elements. Mutations may or may not produce discernible changes in the observable characteristics (phenotype) of an organism. Mutations play a part in both normal and abnormal biological processes including: evolution, cancer, and the development of the immune system, including junctional diversity.
Mutation can result in many different types of change in sequences. Mutations in genes can either have no effect, alter the product of a gene, or prevent the gene from functioning properly or completely. Mutations can also occur in nongenic regions. One study on genetic variations between different species of Drosophila suggests that, if a mutation changes a protein produced by a gene, the result is likely to be harmful, with an estimated 70 percent of amino acid polymorphisms that have damaging effects, and the remainder being either neutral or marginally beneficial. Due to the damaging effects that mutations can have on genes, organisms have mechanisms such as DNA repair to prevent or correct mutations by reverting the mutated sequence back to its original state.
A mutation is a change in the sequence of an organism's genetic material.
Mutation may also refer to:
Mutations is an album by pianist Vijay Iyer recorded in 2013 and released on the ECM label in 2014.
The Allmusic review by Thom Jurek awarded the album 4½ stars out of 5, stating "Mutations rewards with well-considered, inspired performances". Writing for All About Jazz, John Kelman said "Mutations is a landmark recording from an artist who, while already possessing an admirable discography, has clearly been limited to more decidedly jazz-oriented concerns. Representing a significant musical shift, if Mutations is but the first sign of the greater freedom ECM plans to afford Iyer, the only vaticinator of what's to follow will surely be its complete and utter unpredictability".The Guardian review by John Fordham awarded the album 4 stars noting "It's thoughtful, typically original, and unexpectedly very exciting".
Not all reviews were as enthusiastic with JazzTimes stating "Mutations is a major disappointment. The problem is Iyer’s writing for strings. There is a 10-part suite for string quartet, piano and electronics. The suite is stunningly devoid of the aesthetic and emotional content that makes most people listen to music. Qualities such as lyric discovery, melodic fulfillment and rhythmic engagement are absent".
Kone Oyj (officially typeset KONE and pronounced /ko.ne/), founded in 1910 and headquartered in Helsinki, Finland, is an international engineering and service company employing some 43,000 personnel worldwide. The firm is one of the largest manufacturers of elevators and escalators worldwide, and also provides maintenance services and modernization solutions. In addition, KONE builds and services automatic doors and gates. The company provides local service for builders, developers, building owners, designers and architects in 1,000 offices in over 50 countries. Since 1924, KONE has been owned by one of Finland's wealthiest families, the Herlin family. After Harald Herlin purchased the company in 1924, he served as its Chairman until 1941. Afterwards, his son, Heikki H. Herlin, took over his father's post from 1941–1987. Control of the company was then handed down to his son, Pekka Herlin, which he retained from 1987–2003. The current Chairman of KONE's Board of Directors from 2003 onwards is Antti Herlin, the son of Pekka Herlin.
Kone is a volcano located in the Oromia region of Ethiopia. It is located on the Main Ethiopian Rift, which belongs to the most northern branch of the East African Rift Valley.Borchotto the nearest town is 5 km away and the capital of Ethiopia, Addis Ababa is situated 160 km west of Kone. The nearest volcano is Fentale located 30 km to the North West, with the Boseti Gudo Volcano further away to the South East. Kone takes up an area of 250 square miles and has an elevation of 1619m.
The complex tectonic history within Ethiopia has made the eruption history difficult to interpret from the Stratigraphic sequence. From the stratigraphy four volcanic sequences of eruption can be determined. Three Silicic phases and then a basalt phase. The most recent basalt phase is dated around 1820. This date corresponds to local legends of the eruption and the lack of vegetation growth on the lava flows provides evidence of this eruption.
Kone, also called Gariboldi, is made up of seven nested calderas, lava flows and basaltic cinder cones. (Not to be confused with the Garibaldi Volcanic Belt in Northern America.) There are two fault lines that have caused the volcanic activity within Kone, normal faults, which are part of the Wonji fault belt and ring fractures. The normal faults cause magma to rise inducing the volcanic activity. The ring fractures have caused the calderas collapse. Both of these faults have caused activity within Kone’s recent history. The calderas widths can range from 1.5 to 5 km.
Tucano (Tukano, Tucana, Tucana; autonym: Dahseyé (Dasea)) is a Tucanoan language spoken in Amazonas, Brazil and Colombia.
Many speakers of the endangered Tariana language are switching to Tucano.