Musakhel is a village and the center of Musakhel District, Khost Province, Afghanistan. It is located at 33°32′00″N 69°44′00″E / 33.5333°N 69.7333°E / 33.5333; 69.7333 at 1835 m altitude.
Khost or Khowst (Pashto/Persian: خوست) is a city in eastern Afghanistan. The capital of Khost Province is Matoon. Khost is a mountainous region near Pakistan's border with neighboring North Waziristan in the Federally Administered Tribal Areas and Bannu in Pakistan. The population of Khost City is about 160,000 people and the whole province has around a million. There are various tribes living in Khost. Some of the main tribes are Zadran, Mangal, Zazi, Tani, Gurbaz, Muqbal, and Sabari. The city of Khost has a population of 106,083 (in 2015). it has 6 districts and a total land area of 7,139 Hectares. The total number of dwellings in this city are 11,787.
During the nine-year Soviet war in Afghanistan in the 1980s, the town was besieged from July 1983 to November 1987. Khost Airfield, with its 9,000-foot (2,700 m) runway, served as a base for helicopter operations for the Soviet military.
American forces have used the Khost Airfield since as early as at least January 2007 during the War in Afghanistan (2001–present) that commenced in October 2001.