Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene.[1][2]
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).[2]
References [link]
- ^ Brugnera E, Georgiev O, Radtke F, Heuchel R, Baker E, Sutherland GR, Schaffner W (Sep 1994). "Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1". Nucleic Acids Res 22 (15): 3167–73. DOI:10.1093/nar/22.15.3167. PMC 310292. PMID 8065932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310292.
- ^ a b "Entrez Gene: MTF1 metal-regulatory transcription factor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4520.
Further reading [link]
- Westin G, Schaffner W (1989). "A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene.". EMBO J. 7 (12): 3763–70. PMC 454951. PMID 3208749. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=454951.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Chen X, Chu M, Giedroc DP (1999). "MRE-Binding transcription factor-1: weak zinc-binding finger domains 5 and 6 modulate the structure, affinity, and specificity of the metal-response element complex". Biochemistry 38 (39): 12915–25. DOI:10.1021/bi9913000. PMID 10504263.
- Otsuka F, Okugaito I, Ohsawa M, et al. (2000). "Novel responses of ZRF, a variant of human MTF-1, to in vivo treatment with heavy metals". Biochim. Biophys. Acta 1492 (2–3): 330–40. PMID 11004505.
- Saydam N, Georgiev O, Nakano MY, et al. (2001). "Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals". J. Biol. Chem. 276 (27): 25487–95. DOI:10.1074/jbc.M009154200. PMID 11306562.
- Saydam N, Adams TK, Steiner F, et al. (2002). "Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription". J. Biol. Chem. 277 (23): 20438–45. DOI:10.1074/jbc.M110631200. PMID 11923282.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Majumder S, Ghoshal K, Summers D, et al. (2003). "Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1". J. Biol. Chem. 278 (28): 26216–26. DOI:10.1074/jbc.M302887200. PMC 2365495. PMID 12716893. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2365495.
- Saydam N, Steiner F, Georgiev O, Schaffner W (2003). "Heat and heavy metal stress synergize to mediate transcriptional hyperactivation by metal-responsive transcription factor MTF-1". J. Biol. Chem. 278 (34): 31879–83. DOI:10.1074/jbc.M302138200. PMID 12805380.
- Chen X, Zhang B, Harmon PM, et al. (2004). "A novel cysteine cluster in human metal-responsive transcription factor 1 is required for heavy metal-induced transcriptional activation in vivo". J. Biol. Chem. 279 (6): 4515–22. DOI:10.1074/jbc.M308924200. PMID 14610091.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Balamurugan K, Egli D, Selvaraj A, et al. (2005). "Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison". Biol. Chem. 385 (7): 597–603. DOI:10.1515/BC.2004.074. PMID 15318808.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S (2005). "Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors". Oncogene 24 (13): 2204–17. DOI:10.1038/sj.onc.1208206. PMID 15735762.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. DOI:10.1038/nature04727. PMID 16710414.
External links [link]
- MTF1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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