Mst1r

Macrophage stimulating 1 receptor (c-met-related tyrosine kinase)

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3PLS

Identifiers

Symbols

MST1R; CD136; CDw136; PTK8; RON

External IDs

OMIM: 600168 MGI: 99614 HomoloGene: 1835 ChEMBL: 2689 GeneCards: MST1R Gene

EC number

2.7.10.1

Gene Ontology
Molecular function	• nucleotide binding • receptor activity • macrophage colony-stimulating factor receptor activity • protein binding • ATP binding • enzyme binding
Cellular component	• stress fiber • plasma membrane • integral to plasma membrane
Biological process	• cellular component movement • defense response • signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • multicellular organismal development • single fertilization • positive regulation of cell proliferation • response to virus • positive regulation of MAP kinase activity • innate immune response • positive regulation of protein kinase B signaling cascade
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
49.92 – 49.94 Mb

Chr 9:
107.81 – 107.82 Mb

PubMed search

[1]

[2]

Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene.^[1]^[2]

Interactions [link]

MST1R has been shown to interact with Grb2.^[3]^[4]

References [link]

^ Ronsin C, Muscatelli F, Mattei MG, Breathnach R (May 1993). "A novel putative receptor protein tyrosine kinase of the met family". Oncogene 8 (5): 1195–202. PMID 8386824.
^ "Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4486.
^ Li, B Q; Wang M H, Kung H F, Ronsin C, Breathnach R, Leonard E J, Kamata T (Nov. 1995). "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor". Biochem. Biophys. Res. Commun. (UNITED STATES) 216 (1): 110–8. DOI:10.1006/bbrc.1995.2598. ISSN 0006-291X. PMID 7488076.
^ Iwama, A; Yamaguchi N, Suda T (Nov. 1996). "STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family". EMBO J. (ENGLAND) 15 (21): 5866–75. ISSN 0261-4189. PMC 452340. PMID 8918464. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=452340.

Further reading [link]

Li BQ, Wang MH, Kung HF, et al. (1995). "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor". Biochem. Biophys. Res. Commun. 216 (1): 110–8. DOI:10.1006/bbrc.1995.2598. PMID 7488076.
Wang MH, Ronsin C, Gesnel MC, et al. (1994). "Identification of the ron gene product as the receptor for the human macrophage stimulating protein". Science 266 (5182): 117–9. DOI:10.1126/science.7939629. PMID 7939629.
Gaudino G, Follenzi A, Naldini L, et al. (1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP". EMBO J. 13 (15): 3524–32. PMC 395256. PMID 8062829. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=395256.
Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene 8 (12): 3403–10. PMID 8247543.
Collesi C, Santoro MM, Gaudino G, Comoglio PM (1996). "A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype". Mol. Cell. Biol. 16 (10): 5518–26. PMC 231551. PMID 8816464. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231551.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548.
Iwama A, Yamaguchi N, Suda T (1997). "STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family". EMBO J. 15 (21): 5866–75. PMC 452340. PMID 8918464. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=452340.
Sakamoto O, Iwama A, Amitani R, et al. (1997). "Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility". J. Clin. Invest. 99 (4): 701–9. DOI:10.1172/JCI119214. PMC 507853. PMID 9045873. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=507853.
Follenzi A, Bakovic S, Gual P, et al. (2000). "Cross-talk between the proto-oncogenes Met and Ron". Oncogene 19 (27): 3041–9. DOI:10.1038/sj.onc.1203620. PMID 10871856.
Chen YQ, Zhou YQ, Fisher JH, Wang MH (2002). "Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo". Oncogene 21 (41): 6382–6. DOI:10.1038/sj.onc.1205783. PMID 12214279.
Chen YQ, Zhou YQ, Fu LH, et al. (2002). "Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais". Carcinogenesis 23 (11): 1811–9. DOI:10.1093/carcin/23.11.1811. PMID 12419829.
Zhou YQ, He C, Chen YQ, et al. (2003). "Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential". Oncogene 22 (2): 186–97. DOI:10.1038/sj.onc.1206075. PMID 12527888.
Danilkovitch-Miagkova A, Duh FM, Kuzmin I, et al. (2003). "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4580–5. DOI:10.1073/pnas.0837136100. PMC 153598. PMID 12676986. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=153598.
Rampino T, Gregorini M, Soccio G, et al. (2003). "The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma". Am. J. Surg. Pathol. 27 (6): 779–85. DOI:10.1097/00000478-200306000-00008. PMID 12766581.
Penengo L, Rubin C, Yarden Y, Gaudino G (2003). "c-Cbl is a critical modulator of the Ron tyrosine kinase receptor". Oncogene 22 (24): 3669–79. DOI:10.1038/sj.onc.1206585. PMID 12802274.
Maggiora P, Lorenzato A, Fracchioli S, et al. (2003). "The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness". Exp. Cell Res. 288 (2): 382–9. DOI:10.1016/S0014-4827(03)00250-7. PMID 12915129.
Santoro MM, Gaudino G, Marchisio PC (2003). "The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration". Dev. Cell 5 (2): 257–71. DOI:10.1016/S1534-5807(03)00201-6. PMID 12919677.
Angeloni D, Danilkovitch-Miagkova A, Miagkov A, et al. (2004). "The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation". J. Biol. Chem. 279 (5): 3726–32. DOI:10.1074/jbc.M309342200. PMID 14597639.
van den Akker E, van Dijk T, Parren-van Amelsvoort M, et al. (2004). "Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors". Blood 103 (12): 4457–65. DOI:10.1182/blood-2003-08-2713. PMID 14982882.

This article on a gene on chromosome 3 is a stub. You can help Wikipedia by expanding it.

Protein kinases: tyrosine kinases (EC 2.7.10)

Receptor tyrosine kinases (EC 2.7.10.1)

Growth factor receptors

EGF receptor family	EGFR ERBB2 ERBB3 ERBB4

Insulin receptor family	IGF1R INSR INSRR

PDGF receptor family	CSF1R FLT3 KIT PDGFR (PDGFRA PDGFRB)

FGF receptor family	FGFR1 FGFR2 FGFR3 FGFR4

VEGF receptors family	VEGFR1 VEGFR2 VEGFR3 VEGFR4

HGF receptor family	MET RON

Trk receptor family	NTRK1 NTRK2 NTRK3

EPH receptor family

LTK receptor family

TIE receptor family

ROR receptor family

ROR1
ROR2

DDR receptor family

DDR1
DDR2

PTK7 receptor family

PTK7

RYK receptor family

MuSK receptor family

MUSK

ROS receptor family

ROS1

AATYK receptor family

AXL receptor family

RET receptor family

uncatagorised

STYK1

Non-receptor tyrosine kinases (EC 2.7.10.2)

ABL family	ABL1 ARG

ACK family	ACK1 TNK1

CSK family	CSK MATK

FAK family	FAK PYK2

FES family	FES FER

FRK family	FRK BRK SRMS

JAK family	JAK1 JAK2 JAK3 TYK2

SRC-A family	SRC FGR FYN YES1

SRC-B family	BLK HCK LCK LYN

TEC family	TEC BMX BTK ITK TXK

SYK family	SYK ZAP70

B enzm

1.1

2

3

4

5

6

7

8

10

11

13

14

15-18

2.1

2

3

4

5

6

7

8

2.7.10 2.7.11-12 3.1

2

3

4

5

6

7

3.1.3.48 3.4.21

22

23

24

4.1

2

3

4

5

6

5.1

2

3

4

99

6.1-3

4

5-6

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Interactions [link]

References [link]

Further reading [link]

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