Cobalt
Cobalt is a chemical element with symbol Co and atomic number 27. Like nickel, cobalt in the Earth's crust is found only in chemically combined form, save for small deposits found in alloys of natural meteoric iron. The free element, produced by reductive smelting, is a hard, lustrous, silver-gray metal.
Cobalt-based blue pigments (cobalt blue) have been used since ancient times for jewelry and paints, and to impart a distinctive blue tint to glass, but the color was later thought by alchemists to be due to the known metal bismuth. Miners had long used the name kobold ore (German for goblin ore) for some of the blue-pigment producing minerals; they were so named because they were poor in known metals, and gave poisonous arsenic-containing fumes upon smelting. In 1735, such ores were found to be reducible to a new metal (the first discovered since ancient times), and this was ultimately named for the kobold.
Today, some cobalt is produced specifically from various metallic-lustered ores, for example cobaltite (CoAsS), but the main source of the element is as a by-product of copper and nickel mining. The copper belt in the Democratic Republic of the Congo, Central African Republic and Zambia yields most of the cobalt mined worldwide.
Cobalt (video game)
Cobalt is an action-oriented side-scrolling video game in development by Oxeye Game Studio and published by Mojang. It was released on February 2, 2016 for Microsoft Windows. In addition to the computer versions, a port is being developed for the Xbox 360 and Xbox One.
Gameplay
Cobalt features several different game modes that are available, such as Capture the Plug (a variation of capture the flag), Deathmatch, TeamStrike (with one life each, inspired by Counter-Strike), Survival, and an upcoming Adventure mode. Along with these features, players can create their own maps with the map editor in-game.
Players play as the main character, known as Cobalt. Some key mechanics of the game include bullet time, rolling (to deflect bullets) and punching which can deal damage and knock back explosives. All of which a player can combo together to produce an advanced level of play.
Development
Alpha
Cobalt was released in its alpha stage of development. Updates to subsequent versions of the game are free. The alpha version was initially solely available for the Windows operating system. A Mac OS X version was released on June 27, 2013, but the game was re-announced as a Xbox 360, Xbox One and Windows 10 exclusive in Gamescom 2014.
Cobalt, Ontario
Cobalt is a town in the district of Timiskaming, province of Ontario, Canada, with a population of 1,133 (as per the Canada 2011 Census.)
In 2001 Cobalt was named "Ontario's Most Historic Town" by a panel of judges on the TV Ontario program Studio 2, and in 2002 the "Cobalt Mining District" was designated a National Historic Site of Canada.
History
Silver was discovered in the area in the summer of 1903, during the construction of the Temiskaming & Northern Ontario Railway from North Bay to the communities of Haileybury and New Liskeard, north of Cobalt. Within a few years the area was one of the largest silver producing areas in the world. Speculation over mining stocks led to riots on Wall Street in New York City. The town was incorporated in 1906. Its population swelled and peaked at 7,000. In 1911, silver production exceeded 30,000,000 ounces (937.5 tons). Mining continued until the 1930s, then slowed to a trickle. Activity renewed in the 1950s then slowly dropped off, and there are no longer any operating mines in the area. However, one mill still operates in the area, and exploration for diamonds and other minerals is ongoing.
Mrs.
Mrs. (American English) or Mrs (British English) (Standard English pronunciation /ˈmɪsᵻz/) is a commonly used English honorific used for women, usually for those who are married and who do not instead use another title (or rank), such as Dr, Professor, Ms., President, Dame, Prime Minister, etc. In most Commonwealth countries, a full stop (period) is not used with the title. In the United States and Canada a period is used (see Abbreviation).
Mrs originated as a contraction of the honorific Mistress, the feminine of Mister, or Master, which was originally applied to both married and unmarried women. The split into Mrs for married women and Miss for unmarried began during the 17th century; the 20th century saw the coinage of a new unmarked option Ms.
It is rare for Mrs to be written in a non-abbreviated form, and the unabbreviated word lacks a standard spelling. In literature it may appear as missus or missis in dialogue. A variant in the works of Thomas Hardy and others is "Mis'ess", reflecting its etymology. Misses has been used but is ambiguous, as this is a commonly-used plural for Miss.
MRS
MRS, Mrs, or mrs can refer to:
Adenosine receptor
The adenosine receptors (or P1 receptors) are a class of purinergic G protein-coupled receptors with adenosine as endogenous ligand.
Pharmacology
In humans, there are four types of adenosine receptors. Each is encoded by a separate gene and has different functions, although with some overlap. For instance, both A1 receptors and A2A play roles in the heart, regulating myocardial oxygen consumption and coronary blood flow, while the A2A receptor also has broader anti-inflammatory effects throughout the body. These two receptors also have important roles in the brain, regulating the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors are located mainly peripherally and are involved in processes such as inflammation and immune responses.
Most older compounds acting on adenosine receptors are nonselective, with the endogenous agonist adenosine being used in hospitals as treatment for severe tachycardia (rapid heart beat), and acting directly to slow the heart through action on all four adenosine receptors in heart tissue, as well as producing a sedative effect through action on A1 and A2A receptors in the brain. Xanthine derivatives such as caffeine and theophylline act as non-selective antagonists at A1 and A2A receptors in both heart and brain and so have the opposite effect to adenosine, producing a stimulant effect and rapid heart rate. These compounds also act as phosphodiesterase inhibitors, which produces additional anti-inflammatory effects, and makes them medically useful for the treatment of conditions such as asthma, but less suitable for use in scientific research.
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