Ago

Ago or AGO may refer to:

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Argonaute

The Argonaute protein family plays a central role in RNA silencing processes, as essential catalytic components of the RNA-induced silencing complex (RISC). RISC complex is responsible for the gene silencing phenomenon known as RNA interference (RNAi). Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). Small RNAs guide Argonaute proteins to their specific targets through sequence complementarity (base pairing), which then leads to mRNA cleavage or translation inhibition.

Discovery

The RNA interference (RNAi) was first reported in 1995 by Guo and Kemphues, and similar pathways collectively referred to as RNA silencing were discovered in plants and fungi. The beginning of people’s understanding of the mechanism of RNA silencing began only in 1998 with the experiments of Fire and colleagues demonstrating that double-stranded RNA triggered RNAi. RNA silencing pathways process long RNAs into small RNAs that direct the repression of transcription or translation of nucleic acid targets with sequence corresponding to the small RNAs. These single-stranded RNAs, referred to as guide strands, are incorporated into RNA silencing effectors complexes such as the RNA-induced silencing complex (RISC). These RNA silencing effector complexes contain Argonaute family proteins.

Mosquito

Mosquitoes are small, midge-like flies which comprise the family Culicidae. Females of most species are ectoparasites, whose tube-like mouthparts (called a proboscis) pierce the hosts' skin to consume blood. The word "mosquito" (formed by mosca and diminutive ito) is Spanish for "little fly". Thousands of species feed on the blood of various kinds of hosts, mainly vertebrates, including mammals, birds, reptiles, amphibians, and even some kinds of fish. Some mosquitoes also attack invertebrates, mainly arthropods. Though the loss of blood is seldom of any importance to the victim, the saliva of the mosquito often causes an irritating rash that is a serious nuisance. Much more serious though, are the roles of many species of mosquitoes as vectors of diseases. In passing from host to host, some transmit extremely harmful infections such as malaria, yellow fever, Chikungunya, west Nile virus, dengue fever, filariasis, Zika virus and other arboviruses, rendering it the deadliest animal family in the world.

Mosquito (disambiguation)

Mosquito commonly refers to flying insects of the family Culicidae.

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The Mosquito

The Mosquito or Mosquito alarm is an electronic device used to deter loitering by young people by emitting sound at high frequency, in some versions so it can only be heard by younger people. The devices have attracted controversy on the basis of human rights and discrimination concerns.

The device is marketed as a safety and security tool for preventing youths from congregating in specific areas. As such, it is promoted to reduce anti-social behaviour such as loitering, graffiti, vandalism, drug use, drug distribution, and violence. In the UK, over 3,000 have been sold, mainly for use outside shops and near transport hubs. The device is also sold in Australia, France, Denmark, Italy, Spain, Germany, Switzerland, Canada and the USA.

Critics say that it discriminates against young people and infringes their human rights, while supporters argue that making the Mosquito illegal would infringe the rights of shopkeepers who suffer business losses when "unruly teenagers" drive away their customers. Mosquito distributors have said that they keep standards to ensure that the device is not abused, and Howard Stapleton who invented the device has asked European governments to legislate guidelines governing its use.