Moca (genus)

Moca is a genus of moths in the family Immidae.

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Moca

Moca or MOCA may refer to:

Places

Science and technology

Museums

Other uses

Moca, Espaillat

Moca is the capital of Espaillat province, in the Cibao region of the Dominican Republic, and it is the tenth-largest city of that country. Moca is located 11 miles/18 kilometers away from the country’s second city, Santiago. Known as "La Villa Heroica" (Village of Heroes) due to the amount of men and women from Moca who have played a major role in the Dominican Republic's history in bringing down two dictators, Ulises Heureaux and Rafael Trujillo, and bringing democracy back to the country.

Moca is home to the Corazon Sagrado de Jesus ("Sacred Heart of Jesus") Cathedral. All its pane glass windows were originally brought from Italy depicting the apostles and Jesus' path to the crucifixion. Agriculture forms the primary livelihood of the inhabitants. Plantain and yucca are main crops. Most crops are harvested by hand.

Moca is also recognized for its strong political up bringing. Former dictator Rafael Trujillo owned a house in Moca. In fact, the house is located a few blocks from the church Sagrado Corazon De Jesus (picture above).

Dock3

Dock3 (Dedicator of cytokinesis 3), also known as MOCA (modifier of cell adhesion) and PBP (presenilin-binding protein), is a large (~180 kDa) protein involved in intracellular signalling networks. It is a member of the DOCK-B subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G proteins. Dock3 specifically activates the small G protein Rac.

Discovery

Dock3 was originally discovered in a screen for proteins that bind presenilin (a transmembrane protein which is mutated in early onset Alzheimer's disease). Dock3 is specifically expressed in neurones (primarily in the cerebral cortex and hippocampus).

Structure and function

Dock3 is part of a large class of proteins (GEFs) which contribute to cellular signalling events by activating small G proteins. In their resting state G proteins are bound to Guanosine diphosphate (GDP) and their activation requires the dissociation of GDP and binding of guanosine triphosphate (GTP). GEFs activate G proteins by promoting this nucleotide exchange.