Argonaute

The Argonaute protein family plays a central role in RNA silencing processes, as essential catalytic components of the RNA-induced silencing complex (RISC). RISC complex is responsible for the gene silencing phenomenon known as RNA interference (RNAi). Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). Small RNAs guide Argonaute proteins to their specific targets through sequence complementarity (base pairing), which then leads to mRNA cleavage or translation inhibition.

Discovery

The RNA interference (RNAi) was first reported in 1995 by Guo and Kemphues, and similar pathways collectively referred to as RNA silencing were discovered in plants and fungi. The beginning of people’s understanding of the mechanism of RNA silencing began only in 1998 with the experiments of Fire and colleagues demonstrating that double-stranded RNA triggered RNAi. RNA silencing pathways process long RNAs into small RNAs that direct the repression of transcription or translation of nucleic acid targets with sequence corresponding to the small RNAs. These single-stranded RNAs, referred to as guide strands, are incorporated into RNA silencing effectors complexes such as the RNA-induced silencing complex (RISC). These RNA silencing effector complexes contain Argonaute family proteins.

Miracle (S.O.A.P. album)

Miracle is the second and final album by S.O.A.P.. It was released in 2000 and peaked at No. 20 in Denmark. The album's debut single, S.O.A.P. Is In The Air, charted in Denmark and Sweden, reaching No. 3 and No. 25 respectively.

Track listing

References

External links

Miracle (film)

Miracle is a 2004 American sports docudrama about the United States men's hockey team, led by head coach Herb Brooks, portrayed by Kurt Russell, that won the gold medal in the 1980 Winter Olympics. The USA team's victory over the heavily favored Soviet team in the medal round was dubbed the Miracle on Ice. Miracle was directed by Gavin O'Connor and written by Eric Guggenheim.

Plot

The film chronicles the journey of the 1980 US Olympic Men's ice hockey team. Then University of Minnesota head coach Herb Brooks (Kurt Russell) interviews with the United States Olympic Committee, discussing his philosophy on how to beat the Soviet team, calling for changes to the practice schedule and strategy.

Brooks meets his assistant coach Craig Patrick (Noah Emmerich) at the tryouts in Colorado Springs. Brooks selects a preliminary roster of 26—later to be cut to a final roster of 20—indifferent of the tryouts and the preferences of senior USOC hockey officials. He convinces Walter Bush (Sean McCann), the executive director of the committee, that he has their best interests at heart. Bush reluctantly agrees to take the heat from the committee.

Miracle (Celine Dion album)

Miracle is a concept album credited to Canadian singer Celine Dion and Australian photographer Anne Geddes, released on October 11, 2004. It's Dion's ninth English language studio album and 33rd in total.

Content and release

Miracle is a part of a CD-and-book multimedia collection, with Dion's music providing the soundtrack to Geddes' pictorial book celebrating the joy of babies. The songs were produced by David Foster, who hadn't worked with Dion since 1999.

Among tracks on the album are remakes of John Lennon's "Beautiful Boy," Louis Armstrong's "What a Wonderful World," Roberta Flack's "The First Time Ever I Saw Your Face," Johannes Brahms' "Brahms' Lullaby," Nancy Wilson's "If I Could," Henri Salvador's "Le loup, la biche et le chevalier (une chanson douce)," and Carol Welsman's "Baby Close Your Eyes."

All other tracks are original songs such as the title track, which was written in 2001 for A New Day Has Come to celebrate the birth of Dion's son René-Charles, but the song was never published on that album.