Minaxolone

Minaxolone (CCI-12923) is a neuroactive steroid which was developed as a general anesthetic but was withdrawn before registration due to toxicity seen with long-term administration in rats, and hence was never marketed. It is a positive allosteric modulator of the GABAA receptor, as well as, less potently, a positive allosteric modulator of the glycine receptor.

See also

  • Alfadolone
  • Alfaxolone
  • Ganaxolone
  • Hydroxydione
  • Pregnanolone
  • Renanolone
  • References



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