Professor Michael Spencer Waterman is a scientist at the University of Southern California (USC), where he holds an Endowed Associates Chair in Biological Sciences, Mathematics and Computer Science. He previously held positions at Los Alamos National Laboratory and Idaho State University. He grew up near Bandon, Oregon and earned a bachelor's degree in Mathematics from Oregon State University, followed by a doctorate in statistics and probability from Michigan State University in 1969.
Waterman is one of the founders and current leaders in the area of computational biology. He focuses on applying mathematics, statistics, and computer science techniques to various problems in molecular biology. His work has contributed to some of the most widely used tools in the field. In particular, the Smith-Waterman algorithm (developed with Temple Smith) is the basis for many sequence comparison programs. In 1988, Waterman and Eric Lander published a landmark paper describing a mathematical model for fingerprint mapping. This work formed one of the theoretical cornerstones for many of the later DNA mapping and sequencing projects, especially the Human Genome Project. A 1995 paper by Idury and Waterman introduced Eulerian-De Bruijn sequence assembly which is widely used in next-generation sequencing projects.